Zobrazeno 1 - 10
of 162
pro vyhledávání: ''
Autor:
Pithi Chanvorachote, Preedakorn Chunhacha, Maneewan Suksomtip, Zin Zin Ei, Chanida Vinayanuwattikun, Alisa Tubsuwan, Decha Pinkaew, Kanuengnit Choochuay
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Scientific Reports
Scientific Reports
Cisplatin (CDDP) induces senescence characterized by senescence-associated secretory phenotypes (SASP) and the unfolded protein response (UPR). In this study, we investigated the proteins related to the UPR during the senescence cell fate. Strikingly
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Scientific Reports
Scientific Reports
Transporters in the human liver play a major role in the clearance of endo- and xenobiotics. Apical (canalicular) transporters extrude compounds to the bile, while basolateral hepatocyte transporters promote the uptake of, or expel, various compounds
Autor:
Venketesh Sivaramakrishnan, Rahul Ray, Saibharath Simha Reddy Santha, Sai Krishna Srimadh Bhagavatham, Polani B. Seshagiri, Vishnu Kannan, Sujith Kumar Pulukool, Narsimulu Gumdal, Divya Sridharan, Sai Mangala Divi, Ashish Pargaonkar, Damodaram Potikuri, Ashwin Ashok Naik, Prakash Khanchandani, K. Narasimhan, Rajesh Babu Dandamudi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-22 (2021)
Scientific Reports
Scientific Reports
Rheumatoid Arthritis (RA) is a chronic autoimmune disease associated with inflammation and joint remodeling. Adenosine deaminase (ADA), a risk factor in RA, degrades adenosine, an anti-inflammatory molecule, resulting in an inflammatory bias. We pres
Autor:
Célia R.S. Garcia, Maneesh Kumar Singh, Fahyme Costa, Bárbara K M Dias, Giulliana Tessarin-Almeida, Jude M. Przyborski, Pedro Scarpellli Pereira
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Scientific Reports
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Scientific Reports
The host hormone melatonin is known to modulate the asexual cell-cycle of the human malaria parasite Plasmodium falciparum and the kinase PfPK7 is fundamental in the downstream signaling pathways. The nuclear protein PfMORC displays a histidine kinas
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports
Scientific Reports
Pyrazolone complexes have strong anti-tumor and antibacterial properties, but the anti-tumor mechanism of pyrazolone-based copper complexes has not been fully understood. In this study, the possible mechanism and the inhibitory effect of a novel pyra
Autor:
Justin W.C. Leung, Kimberly J. Krager, Ratan Sadhukhan, Alexei G. Basnakian, Rupak Pathak, Sarthak Garg, Alena V. Savenka
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports
Kruppel-like factor 2 (KLF2) is a positive transcriptional regulator of several endothelial protective molecules, including thrombomodulin (TM), a surface receptor, and endothelial nitric oxide synthase (eNOS), an enzyme that generates nitric oxide (
Autor:
Fayaj A. Mulani, Hariharakrishnan Chidambaram, Nalini Vijay Gorantla, Hirekodathakallu V. Thulasiram, Tushar Dubey, Subashchandrabose Chinnathambi, Rashmi Das
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-19 (2020)
Scientific Reports
Scientific Reports
The Alzheimer’s disease pathology is associated with accumulation of intracellular neurofibrillary tangles and extracellular senile plaques. The formation of initial nucleus triggers conformational changes in Tau and leads to its deposition. Hence,
Autor:
Satoshi Fujii, Midori Iida, Junichi Yamamoto, Shumpei Tateno, Tetsufumi Suwa, Takumi Ito, Hiroshi Handa, Miki Katayama, Satoshi Sakamoto, Yuki Yamaguchi, Haruka Tokuyama
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
Scientific Reports
Pomalidomide, a derivative of thalidomide, is an effective treatment for multiple myeloma. The drug exerts its effects through CRBN, a component of the E3 ubiquitin ligase complex CRL4CRBN. To search for novel factors involved in the anti-cancer acti
Autor:
Vitalba Ruggieri, Claudia Piccoli, Rosella Scrima, Consiglia Pacelli, Tiziana Tataranni, Cristoforo Pomara, Ilaria Laurenzana, Olga Cela, Francesca Agriesti, Francesco Sessa, Nazzareno Capitanio, Monica Salerno, Carmela Mazzoccoli, Gabriele Sani
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-17 (2020)
Scientific Reports
Scientific Reports
Nandrolone is a testosterone analogue with anabolic properties commonly abused worldwide, recently utilized also as therapeutic agent in chronic diseases, cancer included. Here we investigated the impact of nandrolone on the metabolic phenotype in He
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Despite the use of multimodal treatment combinations, the prognosis of glioblastoma (GB) is still poor. To prevent rapid tumor recurrence, targeted strategies for the treatment of GB are widely sought. Here, we compared the efficacy of focused modula