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Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Scientific Reports
Scientific Reports
In human gliomas, anti-tumor T cell responses are inhibited through induction of local and systemic immunosuppression. Immune checkpoint blockade is proving to be a success in several types of cancers. However, many studies reported that the treatmen
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Scientific Reports
Scientific Reports
Recent evidence revealed an inhibitory effect of circ-ITCH on the progression of papillary thyroid cancer via affecting the circ-ITCH/miR-22-3p/CBL axis. Rs4911154, an SNP located in circ-ITHC, was previously reported to be significantly associated w
Autor:
Roger Estrada-Tejedor, Isabel Pont, Beatriz Llamusi, Anna S. Rapisarda, Manuel Pérez-Alonso, Enrique García-España, Ariadna Bargiela, Ruben Artero
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Scientific Reports
Scientific Reports
In Myotonic Dystrophy type 1 (DM1), a non-coding CTG repeats rare expansion disease; toxic double-stranded RNA hairpins sequester the RNA-binding proteins Muscleblind-like 1 and 2 (MBNL1 and 2) and trigger other DM1-related pathogenesis pathway defec
Autor:
Jianrong Yang, Luying Huang, Wan Chen, Liwen Lv, Xing Zhou, Wensheng Lu, Kun Ye, Zhao Fu, Chunxia Chen, Mei Zhong, Zhihuang Nong
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Scientific Reports
Scientific Reports
Pulmonary fibrosis is a devastating disease, and the pathogenesis of this disease is not completely clear. Here, the medical records of 85 Covid-19 cases were collected, among which fibrosis and progression of fibrosis were analyzed in detail. Next,
Autor:
Samatha Bhat, S. Jyothi Prasanna, Raviraja N. Seetharam, Pachaiyappan Viswanathan, Shashank Chandanala
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
Scientific Reports
Scientific Reports
Bone marrow-derived mesenchymal stromal cells (BM-MSCs) are gaining increasing importance in the field of regenerative medicine. Although therapeutic value of MSCs is now being established through many clinical trials, issues have been raised regardi
Autor:
Verstegen, Monique M A, Roos, Floris J M, Burka, Ksenia, Gehart, Helmuth, Jager, Myrthe, de Wolf, Maaike, Bijvelds, Marcel J C, de Jonge, Hugo R, Ardisasmita, Arif I, van Huizen, Nick A, Roest, Henk P, de Jonge, Jeroen, Koch, Michael, Pampaloni, Francesco, Fuchs, Sabine A, Schene, Imre F, Luider, Theo M, van der Doef, Hubert P J, Bodewes, Frank A J A, de Kleine, Ruben H J, Spee, Bart, Kremers, Gert-Jan, Clevers, Hans, IJzermans, Jan N M, Cuppen, Edwin, van der Laan, Luc J W, Interne geneeskunde GD, dCSCA RMSC-1, Sub SBR overig, Faculteit Diergeneeskunde, Dep Biologie, CS_STEM
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Scientific Reports, 10(1):21900. Nature Publishing Group
Scientific Reports, 10(1). Nature Publishing Group
Scientific Reports, 10(1). NLM (Medline)
Scientific Reports
Scientific Reports, 10(1):21900. Nature Publishing Group
Scientific Reports, 10(1). Nature Publishing Group
Scientific Reports, 10(1). NLM (Medline)
Scientific Reports
The development, homeostasis, and repair of intrahepatic and extrahepatic bile ducts are thought to involve distinct mechanisms including proliferation and maturation of cholangiocyte and progenitor cells. This study aimed to characterize human extra
Autor:
Xiao Ming Xu, Risset Silvera, Vladimir Camarena, Gaofeng Wang, Kaiwen Peng, Regina M. Graham, Natalia Denise Andersen, David W. Sant, Gonzalo Piñero, Aisha Khan, Paula V. Monje
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-20 (2020)
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Scientific Reports
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Scientific Reports
Nerve-derived human Schwann cell (SC) cultures are irreplaceable models for basic and translational research but their use can be limited due to the risk of fibroblast overgrowth. Fibroblasts are an ill-defined population consisting of highly prolife
Autor:
Bohumila Jurkovicova-Tarabova, Miriam Kolnikova, Ludevit Kadasi, Lubica Lacinova, Andrea Soltysova, Tomas Foltan, Andrej Ficek, Viktor Demko, Daniela Kluckova
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports
Mutations in the voltage-gated sodium channel Nav1.1 (SCN1A) are linked to various epileptic phenotypes with different severities, however, the consequences of newly identified SCN1A variants on patient phenotype is uncertain so far. The functional i
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports
Smooth muscle cell migration is essential for many diverse biological processes such as pulmonary/cardiovascular development and homeostasis. Abi1 (Abelson interactor 1) is an adapter protein that has been implicated in nonmuscle cell migration. Howe
Autor:
Heng-Pei Ang, Hon Shing Ong, Stephen Wahlig, Khadijah Adnan, F. Morales-Wong, Chan N. Lwin, Matthew Lovatt, Gary S L Peh, Jodhbir S. Mehta
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports
Scientific Reports
As the cornea is one of the most transplanted tissues in the body it has placed a burden on the provision of corneas from cadaveric donors. Corneal endothelial dysfunction is the leading indication for cornea transplant. Therefore, tissue engineering