Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Preclinical research"'
Autor:
P. Joy Dunmore-Buyze, Maria Drangova, Eric Grolman, Elizabeth R. Gillies, David W. Holdsworth, Charmainne Cruje
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports
Scientific Reports
Vascular research is largely performed in rodents with the goal of developing treatments for human disease. Micro-computed tomography (micro-CT) provides non-destructive three-dimensional imaging that can be used to study the vasculature of rodents.
Autor:
Xizhe Wang, N. Patrik Brodin, Maria Maryanovich, Kara L. Watts, Ali H. Zahalka, Chandan Guha, Sandra Pinho, Paul S. Frenette
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
Scientific Reports
Scientific Reports
The prostate is a hormone-responsive organ where testicular androgens drive the proliferation and survival of prostatic cells, ensuring the development and functioning of this gland throughout life. Androgen deprivation therapy leads to apoptosis of
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports
Scientific Reports
Evaluate the feasibility, safety and accuracy of a CT-guided robotic assistance for percutaneous needle placement in the liver. Sixty-six fiducials were surgically inserted into the liver of ten swine and used as targets for needle insertions. All CT
Autor:
Melanie L. Graham, Laura Hocum Stone, Julia L. Nugent, Scott Hunter Oppler, Sarah C. Gresch, Michael P. Murtaugh, Sabarinathan Ramachandran, Bernhard J. Hering, Rebecca L. Hegstad-Davies
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Scientific Reports
Scientific Reports
Cytokine profiling is a valuable tool for monitoring immune responses associated with disease and treatment. This study assessed the impact of sex and sedation on serum cytokines in healthy nonhuman primates (NHPs). Twenty-three cytokines were measur
Autor:
Franco Fais, Fortunato Morabito, Adalberto Ibatici, Serena Matis, Paola Menichini, Gilberto Fronza, Mariella Dono, Massimo Gentile, Antonino Neri, Paola Monti, Simonetta Zupo, Sonia Fabris, Marta Lionetti, Andrea Speciale, Marzia Barbieri, Giuseppa De Luca, Manlio Ferrarini, Giovanna Cutrona, Anna Grazia Recchia, Monica Colombo
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports
Chronic lymphocytic leukaemia (CLL) is characterised by a heterogeneous clinical course. Such heterogeneity is associated with a number of markers, including TP53 gene inactivation. While TP53 gene alterations determine resistance to chemotherapy, it
Autor:
Watcharamat Muangkaew, Kanchana Kengkoom, Passanesh Sukphopetch, Sumate Ampawong, Tapanee Kanjanapruthipong, Theerapong Buaban, Pornanong Aramwit
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports
Scientific Reports
Psoriasis is mainly caused because of inappropriate immune responses in the epidermis. Rice (Oryza sativa L.: SRNC05053-6-2) consists of anthocyanin, which exhibits strong antioxidative and anti-inflammatory properties. This study aimed to evaluate t
Autor:
Rebecca W. Olsen, Trine Staalsoe, Casper Hempel, Michael F. Ofori, Nanna Dalgaard, Lars Hviid, Srinidhi Sudharson, William van der Puije, Jørgen A. L. Kurtzhals, Christian W. Wang
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports
van der Puije, W, Wang, C W, Sudharson, S, Hempel, C, Olsen, R W, Dalgaard, N, Ofori, M F, Hviid, L, Kurtzhals, J A L & Staalsoe, T 2020, ' In vitro selection for adhesion of Plasmodium falciparum-infected erythrocytes to ABO antigens does not affect PfEMP1 and RIFIN expression ', Scientific Reports, vol. 10, no. 1, pp. 12871 . https://doi.org/10.1038/s41598-020-69666-9
Scientific Reports
van der Puije, W, Wang, C W, Sudharson, S, Hempel, C, Olsen, R W, Dalgaard, N, Ofori, M F, Hviid, L, Kurtzhals, J A L & Staalsoe, T 2020, ' In vitro selection for adhesion of Plasmodium falciparum-infected erythrocytes to ABO antigens does not affect PfEMP1 and RIFIN expression ', Scientific Reports, vol. 10, no. 1, pp. 12871 . https://doi.org/10.1038/s41598-020-69666-9
Plasmodium falciparum causes the most severe form of malaria in humans. The adhesion of the infected erythrocytes (IEs) to endothelial receptors (sequestration) and to uninfected erythrocytes (rosetting) are considered major elements in the pathogene
Autor:
Marek Pieczka, Mohamed Arafkas, Alessio Pigazzi, Tanja Khosrawipour, Alice Martino, Sören Reinhard, Veria Khosrawipour, Jacek Bania, Justyna Schubert
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-7 (2020)
Scientific Reports
Scientific Reports
For decades, intraperitoneal chemotherapy (IPC) was delivered into the abdominal cavity as a liquid solution. This preliminary study aims to evaluate foam as a potential new drug carrier for IPC delivery. Foam-based intraperitoneal chemotherapy (FBIC
Autor:
Youn-Ho Lee, Jina Oh, Young-Joon Lee, Sae-Kwang Ku, Phil Hyun Song, Choong-Gon Kim, Dae-Geon Lee, Chang-Hyun Song
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports
Scientific Reports
Balneotherapy is a common non-pharmacological treatment for osteoarthritis (OA), however, the efficacy is controversial in knee OA. Jeju magma-seawater (JMS) has high contents of various minerals, which has anti-inflammatory and antioxidant propertie
Autor:
Hanh N. D. Le, Arthur L. Burnett, Adarsha P. Malla, Serkan Karakus, Jin U. Kang, Jeeun Kang, Maged M. Harraz, Emad M. Boctor
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports
Scientific Reports
Despite current progress achieved in the surgical technique of radical prostatectomy, post-operative complications such as erectile dysfunction and urinary incontinence persist at high incidence rates. In this paper, we present a methodology for func