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Autor:
Venketesh Sivaramakrishnan, Rahul Ray, Saibharath Simha Reddy Santha, Sai Krishna Srimadh Bhagavatham, Polani B. Seshagiri, Vishnu Kannan, Sujith Kumar Pulukool, Narsimulu Gumdal, Divya Sridharan, Sai Mangala Divi, Ashish Pargaonkar, Damodaram Potikuri, Ashwin Ashok Naik, Prakash Khanchandani, K. Narasimhan, Rajesh Babu Dandamudi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-22 (2021)
Scientific Reports
Scientific Reports
Rheumatoid Arthritis (RA) is a chronic autoimmune disease associated with inflammation and joint remodeling. Adenosine deaminase (ADA), a risk factor in RA, degrades adenosine, an anti-inflammatory molecule, resulting in an inflammatory bias. We pres
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Scientific Reports
Scientific Reports
T-cell activation induces context-specific gene expression programs that promote energy generation and biosynthesis, progression through the cell cycle and ultimately cell differentiation. The aim of this study was to apply the omni ATAC-seq method t
Autor:
Jianrong Yang, Luying Huang, Wan Chen, Liwen Lv, Xing Zhou, Wensheng Lu, Kun Ye, Zhao Fu, Chunxia Chen, Mei Zhong, Zhihuang Nong
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Scientific Reports
Scientific Reports
Pulmonary fibrosis is a devastating disease, and the pathogenesis of this disease is not completely clear. Here, the medical records of 85 Covid-19 cases were collected, among which fibrosis and progression of fibrosis were analyzed in detail. Next,
Autor:
David R. Martinez, Tomohiro Kawano, Ursula Rauch, Joseph S. Palumbo, Leah Rosenfeldt, Vanthana Bharathi, Silvio Antoniak, Clare M. Schmedes, Alice Weithauser, Grant J. Egnatz, Yohei Hisada, Michael Bode, Nigel Mackman
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports
Scientific Reports
Protease-activated receptor 1 (PAR1) is widely expressed in humans and mice, and is activated by a variety of proteases, including thrombin. Recently, we showed that PAR1 contributes to the innate immune response to viral infection. Mice with a globa
Autor:
Wei Liu, Lijian Xie, Cuilan Hou, Tingting Xiao, Xiaomin Sun, Meng Xu, Yongwei Zhang, Junmin Zheng, Yun Li
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Scientific Reports
Scientific Reports
Congenital heart defects, one of the most common birth defects, affect approximately 1% of live birth globally and remain the leading cause of infant mortality in developed countries. Utilizing the pathogenicity score and inheritance mode from whole
Autor:
W. G. Li, Matthew D. Ringel, Sandya Liyanarachchi, Pearlly S. Yan, Albert de la Chapelle, Daniel F. Comiskey, Huiling He, Ralf Bundschuh, Altan M. Turkoglu, Pamela Brock
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports
Scientific Reports
Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. The molecular characteristics of histologically normal appearing tissue adjacent to the tumor (NAT) from PTC patients are not well characterized. The aim of this study was t
Autor:
Jayden Yamakaze, Zhe Lu
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Scientific Reports
Scientific Reports
Strongly oxidative H2O2 is biologically important, but if uncontrolled, would lead to tissue injuries. Lactoperoxidase (LPO) catalyzes the redox reaction of reducing highly reactive H2O2 to H2O while oxidizing thiocyanate (SCN−) to relatively tissu
Autor:
Shungo Hikoso, Kiyoshi Masuyama, Jun Li, Yuki Kuramoto, Shuichiro Higo, Shigeru Miyagawa, Akihito Hashimoto, Issei Komuro, Yoshiki Sawa, Atsuhiko T. Naito, Yasushi Sakata, Hideki Yasutake, Jong-Kook Lee, Kyoko Hidaka
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Scientific Reports
Scientific Reports
Duchenne muscular dystrophy (DMD) is characterized by progressive muscle degeneration accompanied by dilated cardiomyopathy. Recently, abnormality of yes-associated protein (YAP) has been reported as the pathogenesis of muscle degeneration of DMD; ho
Autor:
Ugo De Giorgi, Maria Maddalena Tumedei, Giovanni Paganelli, Monica Celli, Federica Matteucci, Roberta Gunelli, Sara Bravaccini, Sara Ravaioli, Maurizio Puccetti
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
Scientific Reports
Scientific Reports
Bladder cancer (BCa) patients are diagnosed by cytology and cystoscopy. However, these diagnostic tests bear some limitations. We sought for reliable biomarkers to better determine BCa extension. Prostate-specific membrane antigen (PSMA) appears to f
Autor:
Jacqueline V. Schiesser, Thomas Loudovaris, Helen E. Thomas, Edouard G. Stanley, Andrew G. Elefanty
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Scientific Reports
Scientific Reports
The identification of cell surface markers specific to pancreatic beta cells is important for both the study of islet biology and for investigating the pathophysiology of diseases in which this cell type is lost or damaged. Following analysis of publ