Zobrazeno 1 - 10
of 252
pro vyhledávání: '"Preclinical research"'
Autor:
Robert D. Johnston, Caitríona Lally, Celine Smekens, Alan J. Stone, Syed Salman Shahid, Christian Kerskens, Robert Gaul, Brooke Tornifoglio
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Scientific Reports
Scientific Reports
The purpose of this study was to characterize the alterations in microstructural organization of arterial tissue using higher-order diffusion magnetic resonance schemes. Three porcine carotid artery models namely; native, collagenase treated and dece
Autor:
P. Joy Dunmore-Buyze, Maria Drangova, Eric Grolman, Elizabeth R. Gillies, David W. Holdsworth, Charmainne Cruje
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports
Scientific Reports
Vascular research is largely performed in rodents with the goal of developing treatments for human disease. Micro-computed tomography (micro-CT) provides non-destructive three-dimensional imaging that can be used to study the vasculature of rodents.
Autor:
Greg Jensen, Vincent P. Ferrera, Nancy Kwon, Mark Burgess, Elisa E. Konofagou, Robin Ji, Fabian Munoz, Hermes A. S. Kamimura, Andrew F. Teich, Antonios N. Pouliopoulos, Alicia J McLuckie, Anna Meaney, Yusuke Niimi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Scientific Reports
Scientific Reports
An emerging approach with potential in improving the treatment of neurodegenerative diseases and brain tumors is the use of focused ultrasound (FUS) to bypass the blood–brain barrier (BBB) in a non-invasive and localized manner. A large body of pre
Autor:
Yutaka Kawakami, Takashi Tagami
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Scientific Reports
Scientific Reports
Clinicians often perform pumping of infusions with a syringe (PIS) to quickly deliver fluid or blood transfusion to patients, especially during an emergency. Despite the efforts of the clinicians, critically ill patients are prone to acquire catheter
Autor:
Lee E. Fisher, Liane Wong, Bryan McLaughlin, Charles C. Horn, Jonathan A. Shulgach, Michael Sciullo, Derek M. Miller, Ameya C. Nanivadekar, Bill J. Yates, Dylan W. Beam, John I. Ogren, Stephanie Fulton
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Scientific Reports
Scientific Reports
Dysfunction and diseases of the gastrointestinal (GI) tract are a major driver of medical care. The vagus nerve innervates and controls multiple organs of the GI tract and vagus nerve stimulation (VNS) could provide a means for affecting GI function
Autor:
Aleksander A. Mathé, Pia Steensland, Philippe A. Melas, Malin Wirf, Helder André, Nitya Jayaram-Lindström
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports
Scientific Reports
Alcohol use disorders (AUD) often co-occur with anxiety and depressive disorders, and anxiety often drives relapse during alcohol abstinence. Optimal AUD pharmacotherapies may thus need to target both excessive alcohol intake and elevated anxiety. (
Autor:
Opa Vajragupta, Peththa Wadu Dasuni Wasana, Pornchai Rojsitthisak, Pasarapa Towiwat, Hasriadi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Scientific Reports
Scientific Reports
The failure to develop analgesic drugs is attributed not only to the complex and diverse pathophysiology of pain in humans but also to the poor experimental design and poor preclinical assessment of pain. Although considerable efforts have been devot
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports
Scientific Reports
The main goal of this study is to identify the association between corneal shape, elevation, and thickness parameters and visual field damage using machine learning. A total of 676 eyes from 568 patients from the Jichi Medical University in Japan wer
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports
Scientific Reports
Much research effort is being invested into the development of porous biomaterials that enhance implant osseointegration. Large micromotions at the bone-implant interface impair this osseointegration process, resulting in fibrous capsule formation an
Autor:
Laura A. Wilsdon, Peter J. Psaltis, Stephen J. Nicholls, Christina A. Bursill, Paul Zimmet, Kaitlin R. Morrison, Alex Brown, Carmel Bilu, Noga Kronfeld-Schor, Joanne T.M. Tan, Victoria A. Nankivell
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Scientific Reports
Scientific Reports
Type 2 diabetes mellitus (T2DM) increases cardiac inflammation which promotes the development of cardiac fibrosis. We sought to determine the impact of circadian disruption on the induction of hyperglycaemia, inflammation and cardiac fibrosis. Method