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Publikováno v:
Scientific Reports. 13
Deficits in arousal and stress responsiveness are a feature of numerous psychiatric disorders including depression and anxiety. Arousal is supported by norepinephrine (NE) released from specialized brainstem nuclei, including the locus coeruleus (LC)
Autor:
Dina K Gaynullina, Lyubov D Shilova, Olga S. Tarasova, Ekaterina K Selivanova, Anastasia A. Shvetsova
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports
Scientific Reports
Intrauterine growth restriction (IUGR) is one of the most common pathologies of pregnancy. The cardiovascular consequences of IUGR do not disappear in adulthood and can manifest themselves in pathological alterations of vasomotor control. The hypothe
Autor:
Una Goncin, Volker Gerdts, Darryl Falzarano, Mara McNeil, Mark J. Cameron, Brian Richardson, Anni Ge, Roger D. Pechous, Cheryl M. Cameron, Jason Kindrachuk, Mary K. Foley, Magen E. Francis, Jocelyne Lew, Steven Machtaler, Alyson A. Kelvin, Melissa Rioux, Christopher D. Richardson
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
bioRxiv
article-version (status) pre
article-version (number) 1
bioRxiv
article-version (status) pre
article-version (number) 1
SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) hospitalizations and deaths disportionally affect males and the elderly. Here we investigated the impact of male sex and age by infecting adult male, aged male, and adult female ferrets wit
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Scientific Reports
Scientific Reports
Serotonin (5-HT) is a key neuromodulator of medial prefrontal cortex (mPFC) functions. Pharmacological manipulation of systemic 5-HT bioavailability alters the electrical activity of mPFC neurons. However, 5-HT modulation at the population level is n
Autor:
Thomas Stehr, Sören Krach, Michael Haberhausen, Inge Kamp-Becker, Annalina V. Mayer, Sanna Stroth, Peter Alter, Anne-Kathrin Wermter, Frieder M. Paulus
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Scientific Reports
Scientific Reports
Evidence suggests that intranasal application of oxytocin facilitates empathy and modulates its underlying neural processes, which are often impaired in individuals with autism spectrum disorders (ASD). Oxytocin has therefore been considered a promis
Autor:
Donghyeon Suh, Tae-hee Kim, Ji-Young Lee, Nina Ha, Daekwon Bae, Jinsol Park, Da Som Jeong, Hee Seon Lim, Woo-Chan Son, Jiyeon Baek, Soo Min Ko
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Scientific Reports
Scientific Reports
Despite advances in therapeutic strategies for multiple sclerosis (MS), the therapy options remain limited with various adverse effects. Here, the therapeutic potential of CKD-506, a novel HDAC6-selective inhibitor, against MS was evaluated in mice w
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports
Scientific Reports
Heart rate (HR) and sinoatrial node (SAN) function are modulated by the autonomic nervous system. HR regulation by the parasympathetic nervous system (PNS) is impaired in diabetes mellitus (DM), which is denoted cardiovascular autonomic neuropathy. W
Autor:
Takako Suzuki, Jun Takahashi, Makoto Saito, Tomonori Kobayakawa, Yukio Nakamura, Akiko Miyazaki
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Scientific Reports
Scientific Reports
Denosumab and romosozumab, a recently approved new drug, are effective and widely known molecular-targeted drugs for postmenopausal osteoporosis treatment. However, no studies have directly compared their therapeutic effects or safety in postmenopaus
Autor:
Bruno Durante da Silva, Humberto Dellê, Gizele Alves Neves, Robson Luiz Bandoni, Fernanda Marciano Consolim-Colombo, Maria Helena Mattos Porter, Tercio Lemos de Moraes, Valentin A. Pavlov, Kátia De Angelis, Luis Ulloa, Pamela Nithzi Bricher Choque, Maria Claudia Irigoyen
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Scientific Reports
Scientific Reports
The mechanisms regulating immune cells recruitment into the heart during healing after an acute myocardial infarction (AMI) have major clinical implications. We investigated whether cholinergic stimulation with pyridostigmine, a cholinesterase inhibi
Autor:
Akira Murakami, Ken Nagino, Kenta Fujio, Jaemyoung Sung, Ai Yanagawa, Jun Zhu, Mizu Kuwahara, Yasutsugu Akasaki, Yuichi Okumura, Takenori Inomata, Tsuyoshi Saitoh, Atsuko Eguchi, Maria Miura, Hurramhon Shokirova, Kunihiko Hirosawa, Hiroshi Nagase, Keiichi Fujimoto
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Scientific Reports
Scientific Reports
Corneal neovascularization (CNV) causes higher-order aberrations, corneal edema, ocular inflammation, and corneal transplant rejection, thereby decreasing visual acuity. Here, we investigated the effects of topical administration of the kappa opioid