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Autor:
Maria Jenvin Støen, Sigve Andersen, Ana Paola Lombardi, Lise Martine Ingebriktsen, Thomas Karsten Kilvær, Tom Donnem, Elin Richardsen, Lill-Tove Busund, Mehrdad Rakaee, Roy M. Bremnes, Mona Irene Pedersen
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports
Scientific Reports
MicroRNAs (miRs) are small non-coding RNA molecules, which are involved in the development of various malignancies, including prostate cancer (PCa). miR-17-5p is considered the most prominent member of the miR-17-92 cluster, with an essential regulat
Autor:
Shigeo Hisamori, Shigeru Tsunoda, Yasunori Deguchi, Hiroaki Hata, Dai Manaka, Yoshio Kadokawa, Yoshiharu Sakai, Kazutaka Obama, Hiroshi Okabe, Seiichiro Kanaya, Tatsuto Nishigori, Sachiko Minamiguchi, Daiju Yokoyama
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports
Scientific Reports
IntroductionPoor Trastuzumab (Tmab) response in human epidermal growth factor receptor 2-overexpressing gastric or gastroesophageal junction adenocarcinoma (HER2-GEA) is reported to be associated with loss of phosphatase and tensin homolog (PTEN) exp
Autor:
Panpan Wang, Ruojin Ma, Xiaojie Li, Yunyun Ma, Sulei Pang, Xiao-yu Yang, Chun-ge Song, Yan Wang
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Scientific Reports
Scientific Reports
This study aimed to explore the role of LINC00665, miR-4458 and DOCK1 and their interactions in the development of acute myeloid leukemia (AML). The relative expression of LINC00665, miR-4458 and DOCK1 in AML samples was measured using qRT-PCR, and t
Autor:
Qinfeng Mu, Jun Zhang, Ying Zhou, Haixiang Xue, Tongbing Chen, Jisheng Liu, Miaomei Yu, Guanghua Luo
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
Scientific Reports
Scientific Reports
Prior studies have shown that apolipoprotein M (APOM) is involved in the development of some cancers. Here we investigated the effects of APOM on larynx cancer (LC). 20 patients with vocal cord polyps and 18 patients with LC were included in this stu
Autor:
Peter Bergman, Laia Gorchs, Alisa Knauf, Elena Rangelova, Rainer Heuchel, Chanté Mayer, Sultan Ahmed, Mattias Svensson, Carlos Fernández Moro, Helen Kaipe
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports
Scientific Reports
The pancreatic tumour stroma is composed of phenotypically heterogenous cancer-associated fibroblasts (CAFs) with both pro- and anti-tumorigenic functions. Here, we studied the impact of calcipotriol, a vitamin D3 analogue, on the activation of human
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
Scientific Reports
Scientific Reports
Colon cancer is the third most common cancer and a significant cause of cancer-related deaths worldwide. Metastasis is the most insidious aspect of cancer progression. Convincing data suggest that microRNAs (miRs) play a key function in colon cancer
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Scientific Reports
Scientific Reports
Esophageal cancer (ECa) remains a major cause of mortality across the globe. The expression of EIF3J-AS1 is altered in a plethora of tumors, but its role in ECa development and progression are undefined. Here, we show that EIF3J-AS1 is up-regulated i
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports
Scientific Reports
Non-small cell lung cancer (NSCLC) is a common type of lung cancer, characterized by a poor prognosis. In the last several years, more and more studies have demonstrated the significant roles played by circular RNAs (circRNAs) in different human tumo
Autor:
Yong Joon Kim, Sung Eun Kim, Sang Kyum Kim, Seo Hee Kim, Sung Chul Lee, Christopher Seungkyu Lee
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Scientific Reports
Scientific Reports
Recent experimental studies have demonstrated an essential role for the Hippo-Yes-associated protein (YAP) pathway in GNAQ/GNA11-induced tumorigenesis in uveal melanoma (UM). However, the association between YAP activity and clinical outcomes remains
Autor:
Jae Hyeon Kim, Ja-Lok Ku, Seung-Yong Jeong, Hyunsoo Kim, Min Jung Kim, Young Kyoung Shin, Ji Won Park, Nahyun Jeong, Soon Chan Kim
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
Scientific Reports
Colorectal cancer (CRC) represents the third most frequently diagnosed malignancy worldwide and is the second most common cause of tumor-associated mortalities in Korea. Due to the disease’s aggressive behavior, the 5-year survival rate for CRC pat