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Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Alzheimer’s disease (AD), the predominant form of dementia, is a growing global challenge, emphasizing the urgent need for accurate and early diagnosis. Current clinical diagnoses rely on radiologist expert interpretation, which is prone t
Externí odkaz:
https://doaj.org/article/5d875717374a4001a9143e60223672d0
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Understanding the exact pathophysiological mechanisms underlying the involvement of triggering receptor expressed on myeloid cells 2 (TREM2) related microglia activation is crucial for the development of clinical trials targeting microglia a
Externí odkaz:
https://doaj.org/article/19569c4b0ad94b9f83ae39c014d28a53
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Alzheimer’s Disease and Related Dementias (ADRD) affect millions of people worldwide, with mortality rates influenced by several risk factors and exhibiting significant heterogeneity across geographical regions. This study aimed to investi
Externí odkaz:
https://doaj.org/article/9c9fbfaf332b45be9e835bbbfeab2f22
Autor:
Sarvesh Sabarathinam
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Quercetin is a flavonoid with notable pharmacological effects and promising therapeutic potential. Quercetin plays a significant role in neuroinflammation, which helps reduce Alzheimer's disease (AD) severity. Quercetin (Q) and quercetin 3-O
Externí odkaz:
https://doaj.org/article/36f1dcef5428450a9e98c42be0c376c1
Autor:
Nasim Bahram Sangani, Jarno Koetsier, Jonathan Mélius, Martina Kutmon, Friederike Ehrhart, Chris T. Evelo, Leopold M. G. Curfs, Chris P. Reutelingsperger, Lars M. T. Eijssen
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Due to its involvement in physiological and pathological processes, histone deacetylase 6 (HDAC6) is considered a promising pharmaceutical target for several neurological manifestations. However, the exact regulatory role of HDAC6 in the cen
Externí odkaz:
https://doaj.org/article/df6e6d5918da4d449dba8e00be5fbf47
Autor:
Alexandre Poirier, Cynthia Picard, Anne Labonté, Isabelle Aubry, Daniel Auld, Henrik Zetterberg, Kaj Blennow, the PREVENT-AD research group, Michel L. Tremblay, Judes Poirier
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract We examined the role of protein tyrosine phosphatase receptor sigma (PTPRS) in the context of Alzheimer’s disease and synaptic integrity. Publicly available datasets (BRAINEAC, ROSMAP, ADC1) and a cohort of asymptomatic but “at risk” i
Externí odkaz:
https://doaj.org/article/5c2bffc8281e4d86b7cc862b69f180cb
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract The pathogenesis of Alzheimer's disease (AD) remains unclear, but revealing individual differences in functional connectivity (FC) may provide insights and improve diagnostic precision. A hierarchical clustering-based autoencoder with functi
Externí odkaz:
https://doaj.org/article/b7f0fff638f749ef899f10a25884dbe9
Autor:
Bayard Rogers
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Numerous prospective biomarkers are being studied for their ability to diagnose various stages of Alzheimer’s disease (AD). High-density electroencephalogram (EEG) methods show promise as an accurate, economical, non-invasive approach to m
Externí odkaz:
https://doaj.org/article/ee403c65115b43f79fc92a0e0365d29e
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Alzheimer disease (AD) is among the most chronic neurodegenerative diseases that threaten global public health. The prevalence of Alzheimer disease and consequently the increased risk of spread all over the world pose a vital threat to human
Externí odkaz:
https://doaj.org/article/6dbc5ff8341941e18dc0b9db2bd6e09d
Autor:
Hidehiko Okazawa, Munenobu Nogami, Shota Ishida, Akira Makino, Tetsuya Mori, Yasushi Kiyono, Masamichi Ikawa
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-8 (2024)
Abstract The glymphatic system is considered to play a pivotal role in the clearance of disease-causing proteins in neurodegenerative diseases. This study employed MR diffusion tensor imaging (DTI) to evaluate glymphatic system function and its corre
Externí odkaz:
https://doaj.org/article/da03fac5fd2d41f1a9626f13f00cf7c7