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Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Scientific Reports
Scientific Reports
Mutations in PSEN1, PSEN2, or APP genes are known to be causative for autosomal dominant Alzheimer’s disease (ADAD). While more than 400 mutations were reported worldwide, predominantly PSEN1, over 40 mutations have been reported in Han Chinese and
Autor:
Miguel Garcia, M. Rivero, Javier Crespo, Álvaro Díaz-González, M. Pascual, Laura Rasines, C. Del Pozo, Beatriz Castro
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Scientific Reports
Scientific Reports
Inflammatory bowel diseases (IBD) belong to the group of immune-mediated diseases (IMIDs). The effect of associated IMIDs in the prognosis in IBD is nowadays unknown. To describe IMIDs associated to IBD patients and evaluate differences linked to the
Autor:
David H. Ebb, Cassandra Garbutt, Christopher E. Lietz, Brian Lawney, Vikram Deshpande, Zhenfeng Duan, Yen-Lin Chen, Francis J. Hornicek, Dimitrios Spentzos, Santiago A. Lozano-Calderon, G. Petur Nielsen, Benjamin Haibe-Kains, Gregory M. Cote, John Quackenbush, William T. Barry, Yaoyu E. Wang, Edwin Choy
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific reports, vol 10, iss 1
Scientific Reports
Scientific reports, vol 10, iss 1
Scientific Reports
BackgroundThere is a lack of well validated biomarkers in osteosarcoma, a rare, recalcitrant disease with variable outcome and poorly understood biologic behavior, for which treatment standards have stalled for decades. The only standard prognostic f
Autor:
Hanqi Tang, Wen Zhang, Panpan Zhang, Jiuliang Zhao, Hua Chen, Yunyun Fei, Di Wu, Xuan Zhang, Shangzhu Zhang, Huaxia Yang, Yan Zhao, Xiaofeng Zeng, Fengchun Zhang, Linyi Peng
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-7 (2020)
Scientific Reports
Scientific Reports
This prospective cohort study aims to investigate the incidence, related factors and prognosis of IgG4-related disease (IgG4-RD) with malignancies in the Chinese cohort. We prospectively analyzed the IgG4-RD patients recruited in Peking Union Medical
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Epidemiologic observations suggest that exposure to ambient fine particulate matter (PM2.5) is associated with increased risk of chronic kidney disease (CKD) and diabetes, a causal driver of CKD. We evaluated whether diabetes mediates the association
Autor:
Monica Lane, Clemens R. Scherzer, Kate Zhang, Wenfei Zhang, Catherine Viel, Petra Oliva, S. Pablo Sardi, Roy N. Alcalay, Lamya S. Shihabuddin, Pavlina Wolf, Melissa S. Rotunno, Anne-Marie Wills
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
Scientific Reports
Parkinson’s disease, the most common age-related movement disorder, is a progressive neurodegenerative disease with unclear etiology. Better understanding of the underlying disease mechanism(s) is an urgent need for the development of disease-modif
Autor:
Valeria Lifke, Oskar Hansson, John Q. Trojanowski, Niklas Mattsson, Leslie M. Shaw, Jon B. Toledo, Udo Eichenlaub, Katharina Buck, Simone Wahl, Kaj Blennow, Erik Stomrud, Maryline Simon
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports
Scientific Reports
We evaluated the performance of CSF biomarkers for predicting risk of clinical decline and conversion to dementia in non-demented patients with cognitive symptoms. CSF samples from patients in two multicentre longitudinal studies (ADNI, n = 619; BioF
Autor:
Marcia V. Fournier, Adam Brufsky, Joan Chen, Susan Tannenbaum, John C. Obenauer, Edward C. Goodwin
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Scientific Reports
Scientific Reports
We developed a test to predict which patients will achieve pathological complete response (pCR) to neoadjuvant chemotherapy (NAC) and which will have residual disease (RD). Gene expression data from pretreatment biopsies of patients with all breast c
Autor:
Laguzzi, Federica, Maitusong, Buamina, Strawbridge, Rona J., Baldassarre, Damiano, Veglia, Fabrizio, Humphries, Steve E., Rauramaa, Rainer, Kurl, Sudhir, Smit, Andries J., Giral, Philippe, Silveira, Angela, Tremoli, Elena, Hamsten, Anders, de Faire, Ulf, Gigante, Bruna, Leander, Karin, Sirtori, C. R., Calabresi, L., Amato, M., Frigerio, B., Ravani, A., Sansaro, D., Tedesco, C., Coggi, D., Capra, N., Bonomi, A., Eriksson, P., Cooper, J., Acharya, J., Savonen, K., Huttunen, K., Rauramaa, E., Penttila, I. M., Törrönen, J., van Gessel, A. I., van Roon, A. M., Nicolai, A., Mulder, D. J., Kontush, A., Carrié, A., Gallo, A., Karppi, J., Nurmi, T., Nyyssönen, K., Tuomainen, T. P., Tuomainen, J., Kauhanen, J., Sennblad, B., Pirro, M., Vaudo, G., Siepi, D., Lupattelli, G., Mannarino, M. R., Bianconi, V.
Publikováno v:
Scientific Reports, 11(1):7866. Nature Publishing Group
Scientific Reports
Scientific Reports, Nature Publishing Group, 2021, 11 (1), pp.7866. ⟨10.1038/s41598-021-86324-w⟩
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Scientific Reports
Scientific Reports, Nature Publishing Group, 2021, 11 (1), pp.7866. ⟨10.1038/s41598-021-86324-w⟩
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
The relationship between intake of saturated fats and subclinical atherosclerosis, as well as the possible influence of genetic variants, is poorly understood and investigated. We aimed to investigate this relationship, with a hypothesis that it woul
Autor:
Duk Hee Kang, Dong Ryeol Ryu, Taeyoung Yun, Seung Jung Kim, Hyung Jung Oh, Kyu Bok Choi, Ye Eun Ko, Hye Ah Lee, Yon Su Kim, Yong-Lim Kim
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
Scientific Reports
Scientific Reports
Although subjective global assessment (SGA) is a widely used representative tool for nutritional investigations even among dialysis patients, no studies have examined gender-specific differences in the ability of SGA to predict mortality in hemodialy