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Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Scientific Reports
Scientific Reports
Tristeza is a highly destructive disease of citrus caused by the phloem-limited, flexuous filamentous Citrus tristeza virus (CTV) in the genus Closterovirus and the family Closteroviridae. It has been a major constraint for higher productivity and ha
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
Scientific Reports
We recently developed a piggyback knockdown method that was used to knockdown genes in adult zebrafish. In this method, a vivo morpholino (VMO) piggybacks an antisense deoxyoligonucleotide (dO) into the somatic cells and reduces the cognate mRNA leve
Autor:
Igor Pilawski, Xue Yuan, Pavla Ticha, U.S. Tulu, Benjamin R. Coyac, Jill A. Helms, Jie Pan, Waldemar Hoffmann
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
Scientific Reports
The disconnect between preclinical and clinical results underscores the imperative for establishing good animal models, then gleaning all available data on efficacy, safety, and potential toxicities associated with a device or drug. Mini pigs are a c
Autor:
Anna Ianza, Monica Ramello, Enrico Mini, Giandomenico Roviello, Alberto D'Angelo, Martina Catalano, Raffaele Conca, Lorenzo Dreoni, Roberto Petrioli, Stefania Nobili, Silvia Gasperoni, Michele Aieta
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
Scientific Reports
Scientific Reports
Neutropenia is a common side effect associated with nab-paclitaxel gemcitabine (Nab-Gem) therapy. We retrospectively investigated the association between neutropenia induced by first-line Nab-Gem and survival in metastatic pancreatic carcinoma patien
Autor:
Chengwei Tang, Xiao Ma, Ming Zhou, Chong Zhao, Libin Huang, Jinhang Gao, Huan Tong, Rui Liu, Qinghua Tan, Zhe Feng, Jinsun Jiang, Ling Liu, Ming-Guang Zhang, Zhiyin Huang
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports
Scientific Reports
Duodenal dysbiosis may be potential infection risks in patients with severe acute pancreatitis (SAP). Acid-suppression drugs (ACDs) are widely used in SAP patients in Asian countries. However, the impact of ACDs on duodenal microbiota during the earl
Coxsackievirus infection induces a non-canonical autophagy independent of the ULK and PI3K complexes
Autor:
Chen Seng Ng, Pinhao Xiang, Junyan Shi, Yasir Mohamud, Yuanchao Xue, Honglin Luo, Hui Tang, Huitao Liu
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports
Scientific Reports
Coxsackievirus B3 (CVB3) is a single-stranded positive RNA virus that usurps cellular machinery, including the evolutionarily anti-viral autophagy pathway, for productive infections. Despite the emergence of double-membraned autophagosome-like vesicl
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
Scientific Reports
Mother–child interactions impact child social development and psychological health. This study focused on eye-gaze interactions, especially eye contact as synchronized gaze, which is an important non-verbal communication tool in human interactions.
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports
Scientific Reports
Constipation and REM sleep behaviour disorder (RBD) are the earliest non-motor manifestations of Parkinson’s disease (PD). Among non-motor symptoms of PD, it is unclear whether constipation and RBD at early stages of PD are related to cognitive out
Autor:
Alka Bhatia, Amanjit Bal, Neeraj Khatri, Shivani Jaiswal, Nayudu Nallabelli, Vivek Singh Malik, Deep Maheshwari, Rajesh Kumar, Neenu Jacob, Naresh Sachdeva, Savita Verma
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Scientific Reports
Scientific Reports
Type-1 diabetes (T1D) is an autoimmune disease caused by progressive loss of insulin-producing beta cells in the pancreas. Butyrate is a commensal microbial-derived metabolite, implicated in intestinal homeostasis and immune regulation. Here, we inve
Autor:
David T. Martel, Susan E. Shore
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports
Psychophysical studies characterize hyperacusis as increased loudness growth over a wide-frequency range, decreased tolerance to loud sounds and reduced behavioral reaction time latencies to high-intensity sounds. While commonly associated with heari