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Autor:
Akira Fukuya, Yasuo Takahashi, Masahiro Hirakawa, Yasushi Sato, Hiroshi Miyamoto, Kyoko Hamaguchi, Tetsuji Takayama, Naoki Muguruma, Tamotsu Sagawa, Koshi Fujikawa, Koichi Okamoto
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
Scientific Reports
The primary tumour location is an important prognostic factor for previously untreated metastatic colorectal cancer (mCRC). However, the predictive efficacies of primary tumour location, early tumour shrinkage (ETS), and depth of response (DpR) on mC
Autor:
Kaiqi Kang, Jianguo Li, Zefeng Gao, Jingjing Jia, XianJun Liu, Chunyan Hao, Weiwei Guo, Zhijiang Rong
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports
Scientific Reports
Propionate has been reported to exert antidepressant effects, but high-dose propionate may induce autism-like symptoms in experimental animals through induction of dysbiosis of neurotransmitters. The bi-directional effects of propionate seem to be do
Autor:
Anna Ianza, Monica Ramello, Enrico Mini, Giandomenico Roviello, Alberto D'Angelo, Martina Catalano, Raffaele Conca, Lorenzo Dreoni, Roberto Petrioli, Stefania Nobili, Silvia Gasperoni, Michele Aieta
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
Scientific Reports
Scientific Reports
Neutropenia is a common side effect associated with nab-paclitaxel gemcitabine (Nab-Gem) therapy. We retrospectively investigated the association between neutropenia induced by first-line Nab-Gem and survival in metastatic pancreatic carcinoma patien
Autor:
Chengwei Tang, Xiao Ma, Ming Zhou, Chong Zhao, Libin Huang, Jinhang Gao, Huan Tong, Rui Liu, Qinghua Tan, Zhe Feng, Jinsun Jiang, Ling Liu, Ming-Guang Zhang, Zhiyin Huang
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports
Scientific Reports
Duodenal dysbiosis may be potential infection risks in patients with severe acute pancreatitis (SAP). Acid-suppression drugs (ACDs) are widely used in SAP patients in Asian countries. However, the impact of ACDs on duodenal microbiota during the earl
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
Scientific Reports
Scientific reports, vol 10, iss 1
Scientific Reports
Scientific reports, vol 10, iss 1
Chloroquine (CQ) and hydroxychloroquine (HCQ) are on the World Health Organization’s List of Essential Medications for treating non-resistant malaria, rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). In addition, both drugs are cur
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Scientific Reports
Scientific Reports
The habenula is a phylogenetically conserved epithalamic structure, which conveys negative information via inhibition of mesolimbic dopamine neurons. We have previously shown the expression of kisspeptin (Kiss1) in the habenula and its role in the mo
Autor:
Paschalis Ntolios, George Kouliatsis, Georgia Karpathiou, Evangelia Nakou, Ioannis Kotsianidis, Demosthenes Bouros, Stavros Anevlavis, Marios Froudarakis, Argyrios Tzouvelekis, Vasilios Mihailidis
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-7 (2020)
Scientific Reports
Scientific Reports
Published articles support the effect of chemotherapy in the immune environment of tumors, including lung carcinomas. The role of CD4 + T-cells is crucial for expansion and accumulation of other antigen-specific immune cells, and the participation of
Autor:
Alfredo Berardelli, Giuseppe Di Pietro, Donato Colella, Alessandra Fasolino, Giulia Paparella, Giorgio Cruccu, Andrea Truini, Matteo Bologna, Giulia Di Stefano
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports
Scientific Reports
Spontaneous blink rate is considered a biomarker of central dopaminergic activity. Recent evidence suggests that the central dopaminergic system plays a role in nociception. In the present study, we aimed to investigate whether pain modulates spontan
Autor:
Kota Yano, Hideki Fujii, Takeshi Okanoue, Michihisa Moriguchi, Junji Kamon, Kohichiroh Yasui, Aya Takahashi, Yu Liu, Keiichiroh Okuda, Daiki Takahashi, Atsushi Umemura, Yoshito Itoh, Seita Kataoka, Kanji Yamaguchi, Yusuke Ito, Nozomi Tochiki, Yuya Seko, Hiroshi Ishiba, Shinya Okishio
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
Scientific Reports
We explored the beneficial effects of GW7647, a peroxisome proliferator activated receptor α (PPARα) agonist, and metformin, an anti-diabetic drug on an advanced nonalcoholic steatohepatitis (NASH) model in rodents and investigated the possible mec
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports
Exhaustion of Hepatitis C Virus (HCV)-specific T cells and abnormal B cell function is a hallmark of chronic HCV infection. Direct-acting antiviral (DAA) therapies are effective in achieving sustained virologic response (SVR), however, whether succes