Zobrazeno 1 - 10
of 19
pro vyhledávání: ''
Autor:
Qiong Xia, Huimin Zhang, Jörg J. Goronzy, Timothy M. Gould, Jun Jin, Wenqiang Cao, Cornelia M. Weyand, Daniela Weiskopf, Alba Grifoni, Alessandro Sette, Chulwoo Kim, Xuanying Li
Publikováno v:
Sci Immunol
The nutrient-sensing mammalian target of rapamycin (mTOR) is integral to cell fate decisions after T cell activation. Sustained mTORC1 activity favors the generation of terminally differentiated effector T cells instead of follicular helper and memor
Autor:
Miao Sun, Eva Tolosa, Tessa M. Campbell, Sandra von Hardenberg, Joseph C. Sun, Rebecca A. Marsh, Frank Cichocki, Moneef Shoukier, Theodore T. Drashansky, Dorina Avram, Christine Tao, Yenan T. Bryceson, Tim D. Holmes, Eric Y. Helm, Heinrich Schlums, Cheng-Ying Wu, Yin C. Lin, Robert Månsson, Hongya Han, Samuel C. C. Chiang, Ram Vinay Pandey, Christian Klemann, Colleen M. Lau
Publikováno v:
Science Immunology. 6
Epigenetic landscapes can provide insight into regulation of gene expression and cellular diversity. Here, we examined the transcriptional and epigenetic profiles of seven human blood natural killer (NK) cell populations, including adaptive NK cells.
Autor:
Brandy E. Olin, Jessica Y. Huang, Joseph M. Leal, Miranda R. Lyons-Cohen, Karan Kohli, Michael Y. Gerner, Caleb R. Stoltzfus, Michael Gale
Publikováno v:
Sci Immunol
Microanatomical organization of innate immune cells within lymph nodes (LNs) is critical for the generation of adaptive responses. In particular, steady-state LN-resident dendritic cells (Res cDCs) are strategically localized to intercept lymph-drain
Autor:
Laura Cobb, Dejene M. Tufa, Michael R. Verneris, Seonhui Shim, Ashley Yingst, Renee Woods, Kevin Winkler, Kenneth L. Jones, Tyler Shank, Jessica Lake, Dallas Jones, George Devon Trahan
Publikováno v:
Sci Immunol
Innate lymphoid cells (ILCs) develop from common lymphoid progenitors (CLP), which further differentiate into the common ILC progenitor (CILP) that can give rise to both ILCs and NK cells. Murine ILC intermediates have recently been characterized, bu
Autor:
Karl Herbine, Taku Kambayashi, Michael A. Kohanski, Danielle R. Reed, Brenal K. Singh, Breann L. Brown, De’Broski R. Herbert, Yukinori Tanaka, Edward M. Behrens, Bonnie Douglas, Paul J. Bryce, Tiffany Li Hui Tan, Annabel Ferguson, Li-Yin Hung, Christopher F. Pastore, Kelly Zullo, Nisha Vora, Cailu Lin, Noam A. Cohen
Publikováno v:
Sci Immunol
Interleukin-33 (IL-33) is a pleiotropic cytokine that can promote type 2 inflammation but also drives immunoregulation through Foxp3+Treg expansion. How IL-33 is exported from cells to serve this dual role in immunosuppression and inflammation remain
A discrete subset of epigenetically primed human NK cells mediates antigen-specific immune responses
Autor:
Lisa Kleissl, Christoph Bock, Victoria Stary, Matthias Farlik, J. Strobl, Gottfried Fischer, Wolfgang Weninger, Ram Vinay Pandey, Patrick Starlinger, David Pereyra, Georg Stary
Publikováno v:
Science Immunology. 5
Adaptive features of natural killer (NK) cells have been reported in various species with different underlying mechanisms. It is unclear, however, which NK cell populations are capable of mounting antigen-specific recall responses and how such functi
Autor:
Richard A. McIndoe, Eun Jeong Park, David H. Munn, Nada S. Aboelella, Gary A. Piazza, Zhuoqi Liu, Hongyan Xu, Jiaqi Li, Lirong Pei, Kateryna Fesenkova, Bruce R. Blazar, Zhi-Chun Ding, Gang Zhou, Huidong Shi
Publikováno v:
Sci Immunol
The presence of polyfunctional CD4(+) T cells is often associated with favorable antitumor immunity. We report here that persistent activation of signal transducer and activator of transcription 5 (STAT5) in tumor-specific CD4(+) T cells drives the d
Autor:
Lauren E. Higdon, Jonathan S. Maltzman
Publikováno v:
Science Immunology. 5
Sestrin proteins dampen TCR signaling and induce antigen-independent natural killer-like cytotoxicity in highly differentiated CD8 T cells.
Autor:
Uttiya Basu, Wanwei Zhang, Haiteng Deng, Brice Laffleur, Lekha Nair, Gerson Rothschild, Mingyan Fang, Yiyun Chen, Zhi-Ping Liu, Yuling Chen, Junghyun Lim, Pankaj Kumar Giri, Lennart Hammarström, Jiguang Wang
Publikováno v:
Sci Immunol
B cells undergo two types of genomic alterations to increase antibody diversity: introduction of point mutations into immunoglobulin heavy- and light-chain (IgH and IgL) variable regions by somatic hypermutation (SHM) and alteration of antibody effec
Autor:
Yuying Liu, Bo Huang, Xiaoyu Liang, Xiaohui Zhang, Ke Tang, Yabo Zhou, Nannan Zhou, Tianzhen Zhang, Yunfeng Gao, Zhen Zhang, Yu Hu, Jiadi Lv, Quanli Gao, Zhenfeng Wang, Xinfeng Chen, Mengyu Liu, Feiran Cheng, Yiliang Fang, Jing Xie, Yi Zhang
Publikováno v:
Science Immunology. 5
Cytokine release syndrome (CRS) counteracts the effectiveness of chimeric antigen receptor (CAR) T cell therapy in cancer patients, but the mechanism underlying CRS remains unclear. Here, we show that tumor cell pyroptosis triggers CRS during CAR T c