Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Seung-Jae Lee"'
Autor:
Andrew J. Lee, Changyoun Kim, Seongwan Park, Jaegeon Joo, Baekgyu Choi, Dongchan Yang, Kyoungho Jun, Junghyun Eom, Seung-Jae Lee, Sun Ju Chung, Robert A. Rissman, Jongkyeong Chung, Eliezer Masliah, Inkyung Jung
Publikováno v:
Science Advances. 9
Parkinson’s disease (PD) is a progressive neurodegenerative disorder. However, cell type–dependent transcriptional regulatory programs responsible for PD pathogenesis remain elusive. Here, we establish transcriptomic and epigenomic landscapes of
Autor:
Dongyeop Lee, Hyun-Jun Nam, Chanhee Kang, Jooyeon Sohn, Malene Hansen, Linnea M Adams, Yujin Lee, Eun Ji Kim, Seung-Yeol Park, Murat Artan, Dae-Eun Jeong, Dong Jin Moon, Wooseon Hwang, Seung-Jae Lee, Joo-Yeon Yoo, Mihwa Seo, Jeonghun Yeom, Yoonji Jung, Ozlem Altintas, Youngjae Ryu, Sang Ki Park, Cheolju Lee, Keunhee Seo, Sanguk Kim, Chang Man Ha, Seong Kyu Han, Nari Kim, Ara B. Hwang, Sungeun Ju
Publikováno v:
Science Advances
Description
MON-2, which mediates Golgi-endosome trafficking, mediates mitochondrial inhibition–induced longevity by enhancing autophagy.
The Golgi apparatus plays a central role in trafficking cargoes such as proteins and lipids. Defects
MON-2, which mediates Golgi-endosome trafficking, mediates mitochondrial inhibition–induced longevity by enhancing autophagy.
The Golgi apparatus plays a central role in trafficking cargoes such as proteins and lipids. Defects
Autor:
Seung-Jae Lee, Kiyeon Hwang, Chihyung Yeon, Yuen Chong Li, Donggyun Ku, Kyuhong Lee, Sze Chun Wong
Publikováno v:
Science Advances
Description
Safe travel in public transport amid COVID requires wearing a mask properly, showing effects similar to 2-m social distancing.
Several intensive policies, such as mandatorily wearing masks and practicing social distancing, have
Safe travel in public transport amid COVID requires wearing a mask properly, showing effects similar to 2-m social distancing.
Several intensive policies, such as mandatorily wearing masks and practicing social distancing, have
Publikováno v:
Science Advances
Science Advances, 2021, 7 (24), ⟨10.1126/sciadv.abg5177⟩
Science Advances, 2021, 7 (24), ⟨10.1126/sciadv.abg5177⟩
International audience; Heat shock factor 2 (HSF2) regulates the transcription of the male-specific region of the mouse Y chromosome long arm (MSYq) multicopy genes only in testes, but the molecular mechanism underlying this tissue specificity remain
Autor:
Hye Ji Woo, Seung-Jae Lee, Mi Yoon Chang, Hyogeun Shin, Woong Sun, Wahyu Handoko Wibowo Darsono, Noviana Wulansari, Eun Jin Bae, Il-Joo Cho, Ju Hyun Lee, Sang Hun Lee, Jinil Kim
Publikováno v:
Science Advances. 7
Loss-of-function mutations of DNAJC6, encoding HSP40 auxilin, have recently been identified in patients with early-onset Parkinson’s disease (PD). To study the roles of DNAJC6 in PD pathogenesis, we used human embryonic stem cells with CRISPR-Cas9
Publikováno v:
Science Advances
Testis-specific lncRNA regulates expression of mouse Y chromosome genes and plays a critical role in offspring sex ratio.
Heat shock factor 2 (HSF2) regulates the transcription of the male-specific region of the mouse Y chromosome long arm (MSYq
Heat shock factor 2 (HSF2) regulates the transcription of the male-specific region of the mouse Y chromosome long arm (MSYq
Autor:
Noviana, Wulansari, Wahyu Handoko Wibowo, Darsono, Hye-Ji, Woo, Mi-Yoon, Chang, Jinil, Kim, Eun-Jin, Bae, Woong, Sun, Ju-Hyun, Lee, Il-Joo, Cho, Hyogeun, Shin, Seung-Jae, Lee, Sang-Hun, Lee
Publikováno v:
Science Advances
Human DNAJC6 Parkinson’s disease model reveals disruption of WNT-LMX1A regulatory loop during mDA neuron development.
Loss-of-function mutations of DNAJC6, encoding HSP40 auxilin, have recently been identified in patients with early-onset Park
Loss-of-function mutations of DNAJC6, encoding HSP40 auxilin, have recently been identified in patients with early-onset Park
Autor:
Murat Artan, Seung-Jae Lee, Seung Hyun Han, Sangsoon Park, Ara B. Hwang, Kyong-Tai Kim, Yoonji Jung, Wonsik Shin, Hae-Eun H. Park
Publikováno v:
Science Advances
A conserved protein kinase VRK-1 increases life span by activating a key energy sensor AMPK in the roundworm C. elegans.
Vaccinia virus–related kinase (VRK) is an evolutionarily conserved nuclear protein kinase. VRK-1, the single Caenorhabditi
Vaccinia virus–related kinase (VRK) is an evolutionarily conserved nuclear protein kinase. VRK-1, the single Caenorhabditi
Autor:
Hanseong Kim1, Sojin An1, Yeo Reum Park2, Hara Jang2, Heeseon Yoo2, Sang Ho Park1, Seung Jae Lee2 slee026@jbnu.ac.kr, Uhn-Soo Cho1 uhnsoo@med.umich.edu
Publikováno v:
Science Advances. Oct2019, Vol. 5 Issue 10, p1-8. 8p.