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Autor:
Pearson, Aaron D., Mills, Jeremy H., Song, Yifan, Nasertorabi, Fariborz, Han, Gye Won, Baker, David, Stevens, Raymond C., Schultz, Peter G.
Publikováno v:
Science (New York, N.Y.). 347(6224)
The fleeting lifetimes of the transition states (TSs) of chemical reactions make determination of their three-dimensional structures by diffraction methods a challenge. Here, we used packing interactions within the core of a protein to stabilize the