Zobrazeno 1 - 10
of 309
pro vyhledávání: '"John A"'
Autor:
Lori A. Rowe, Ilya J. Finkelstein, Kamyab Javanmardi, Daniel R. Boutz, Jin Eyun Kim, Shivaprakash Gangappa, Jonathan R. McDaniel, Ralph S. Baric, Dhwani Batra, Maria D. Person, George Georgiou, William N. Voss, Brent L. Iverson, Gregory C. Ippolito, Katia George, Andrew S. Herbert, Yuri Tanno, Foteini Bartzoka, Shawn A. Abbasi, Jason S. McLellan, Jimmy Gollihar, Suryaprakash Sambhara, Daniel Billick, Jule Goike, Chelsea J. Paresi, Whitney Pickens, George Delidakis, Justin S. Lee, Nicole V. Johnson, Yixuan J. Hou, Nianshuang Wang, Andrew P. Horton, Jason J. Lavinder, Jan Pohl, Michelle Gadush, Chia Wei Chou, John M. Dye, Dalton M Towers
Publikováno v:
bioRxiv
Although humoral immunity is essential for control of SARS-CoV-2, the molecular composition, binding epitopes and effector functions of the immunoglobulin G (IgG) antibodies that circulate in blood plasma following infection are unknown. Proteomic de
Autor:
Ian N. Moore, Seyhan Boyoglu-Barnum, Swagata Kar, Bianca M. Nagata, Shayne F. Andrew, Joseph R. Francica, John R. Mascola, Shruti N. Shah, Darin K. Edwards, Samantha J. Provost, Barney S. Graham, John Paul Todd, Venkata Viswanadh Edara, Eun Sung Yang, Daniel Valentin, Katelyn Steingrebe, David C. Montefiori, Andrea Carfi, Maciel Porto, Hanne Leth Andersen, Robert A. Seder, Kizzmekia S. Corbett, Wei Shi, Jack Greenhouse, Mark G. Lewis, Evan Lamb, Adrian B. McDermott, Daniel C. Douek, Serge Zouantcha, Kathryn E. Foulds, Nancy J. Sullivan, Mahnaz Minai, Kevin W. Bock, Britta Flach, Lilin Lai, Katharine Floyd, Angela Choi, Charlene McDanal, Jonathan Fintzi, Alan Dodson, Matthew A. Koch, Mario Roederer, Amy T. Noe, Juan I. Moliva, Saule T. Nurmukhambetova, Mitzi M. Donaldson, Laurent Pessaint, Timothy S. Johnston, Andrew Faudree, Anne P. Werner, Mehul S. Suthar, Barbara J. Flynn, Kai Wu, Anthony L. Cook, Sarah O’Connell, Gabriela S. Alvarado, Lingshu Wang, Yi Zhang, Martha Nason, Dillon R. Flebbe, Matthew Gagne, Olubukola M. Abiona, Renee van de Wetering, Kwanyee Leung
Publikováno v:
Science
Immune correlates of protection can be used as surrogate endpoints for vaccine efficacy. The nonhuman primate (NHP) model of SARS-CoV-2 infection replicates key features of human infection and may be used to define immune correlates of protection fol
Autor:
Martin R. Gaudinski, Lauren A. Chang, Laura Novik, Stephen D. Schmidt, Nicole A. Doria-Rose, John R. Mascola, Ingelise J. Gordon, Avan Antia, Mario Roederer, Amy R. Henry, Rachel L. Davis, Farida Laboune, Tyler Stephens, Barney S. Graham, Olubukola M. Abiona, Christian Hatcher, Kizzmekia S. Corbett, Sandeep Narpala, Chaim A. Schramm, Yi Zhang, Danielle A. Wagner, Samuel Darko, Evan M. Cale, Chloe Adrienna Talana, Kwanyee Leung, Yaroslav Tsybovsky, Nancy J. Sullivan, Lingshu Wang, Alicia T. Widge, Sijy O'Dell, Ralph S. Baric, Christopher D. Stringham, Anthony T. DiPiazza, Adam S. Olia, Sabrina Helmold Hait, Daniel C. Douek, Tongqing Zhou, Emily Phung, Amarendra Pegu, Eun Sung Yang, Peter D. Kwong, Tandile Hermanus, Penny L. Moore, David R. Martinez, Prudence Kgagudi, Sarah O’Connell, Misook Choe, Tracy Liu, Adrian B. McDermott, Alexandra Nazzari, Rosemarie D. Mason, Baoshan Zhang, Olamide K. Oloniniyi, Wei Shi, John Misasi, Julie E. Ledgerwood, Tracy J. Ruckwardt, I-Ting Teng
Publikováno v:
Science. 373
IC80 1.5 to 34.5 nanograms per milliliter). We define the structural and functional determinants of binding for all four VOC-targeting antibodies and show that combinations of two antibodies decrease the in vitro generation of escape mutants, suggest
Autor:
Dhira Joshi, Lucy R. Marshall, Lucy R. Wedderburn, Stavroula Paraskevopoulou, Steve Gamblin, Georgina H. Cornish, Sonia Gandhi, Charles Swanton, John W. McCauley, William Bolland, Svend Kjaer, Nikhil Faulkner, Hannah Rickman, Rachel Ulferts, Philip Hobson, D.J. Benton, Laura E. McCoy, Ana Agua-Doce, Rupert Beale, Annachiara Rosa, Chloe Roustan, Nicola O’Reilly, Catherine F Houlihan, Christopher Earl, Eleni Nastouli, A.G. Wrobel, Rachael Thompson, Brigitta Stockinger, Kirsty Thomson, Catherine Moore, Bethany R. Jebson, Anna Radziszewska, Coziana Ciurtin, Andrew Riddell, Saira Hussain, Emilie Sanchez, Peter Cherepanov, Elizabeth C. Rosser, Meredyth G. Ll Wilkinson, Kevin W. Ng, Ruth Harvey, Philip A. Walker, Hannah Peckham, Judith Heaney, Gee Yen Shin, Moira J. Spyer, George Kassiotis
Publikováno v:
Science (New York, N.y.)
Science
Science
Antibodies predating infection Immunological memory after infection with seasonal human coronaviruses (hCoVs) may potentially contribute to cross-protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Ng et al. report that i
Autor:
Min Ni, Anbo Zhou, Tammy Taylor, Mark G. Lewis, Anthony L. Cook, Maciel Porto, Olga Gonzalez, Neil Stahl, Adelekan Oyejide, Laurent Pessaint, Dharani Ajithdoss, John Dutton, Jack Greenhouse, Kendra J. Alfson, Edward J. Dick, Kathryn Lanza, Richard Copin, Christos A. Kyratsous, Bret J Musser, Kusha Mohammadi, Ricardo Carrion, Vaneesha Ali, Elizabeth Clemmons, Michal Gazi, George D. Yancopoulos, Nicole Negron, Hilary M. Staples, Hanne Leth Andersen, Gurinder S. Atwal, Alina Baum, Andrew J. Murphy, Renita Brown, Yenny Goez-Gazi, Yi Wei, Carmen Bartley, Benjamin Klaffke
Publikováno v:
Science
Science (New York, N.y.)
Science (New York, N.y.)
A beneficial cocktail Since the start of the coronavirus disease 2019 (COVID-19) pandemic, considerable effort has gone into generating and characterizing neutralizing antibodies that could be used as therapeutics. Studies in humanized mice and conva
Autor:
Jerry Kok Yen Chan, Zhaoyuan Liu, Anis Larbi, Abhay P. S. Rathore, Hassen Kared, Jing Wen Hang, Rasha Msallam, Ashley L. St. John, Florent Ginhoux, Jozef Balla, Wilfried A. A. Saron, Benoit Malleret, Charles-Antoine Dutertre
Publikováno v:
Science. 370:941-950
Maternal IgE activates fetal mast cells Mast cells (MCs) are immune cells that participate in allergic reactions through their activation by immunoglobulin E (IgE) antibodies. MCs arise early during mammalian development, but it is unclear whether Ig
Autor:
Moses Awofolaju, Amy E. Baxter, Ajinkya Pattekar, J. Han Noll, Derek A. Oldridge, Ian Frank, Alessandro Sette, E. John Wherry, Paul Bates, Daniela Weiskopf, Eline T. Luning Prak, Elizabeth M Drapeau, Oliva Kuthuru, Michael R. Betts, M. M. Addison, Alba Grifoni, S. C. Kammerman, Justine C. Williams, Sokratis A. Apostolidis, Rishi R. Goel, H. C. Descamps, Kendall A. Lundgreen, Scott E. Hensley, J. T. Hamilton, Sherea Long, E. M. Prager, Laura A. Vella, Justin Kim, Nicholas Han, Jacob T. Hamilton, Y. Kaminskiy, Leticia Kuri-Cervantes, D. Pueschl, Josephine R. Giles, Z. Alam, Christopher M McAllister, A. Rennels, Divij Mathew, Nicole Tanenbaum, Sarah Herring, Kurt D'Andrea, Aaron M. Rosenfeld, D. K. Omran, Philip Hicks, Jeanette Dougherty, Maura McLaughlin, N. Markosyan, J. S. Shilan, A. N. Vanderbeck, A. Pattekar, David S. Khoury, Allison R. Greenplate, Miles P. Davenport, A. Chandra, K. T. Byrne, Madison E. Weirick, A. R. Greenplate, Sigrid Gouma, Mark M Painter, Sarah Dysinger, Harsh Sharma, Amanda Hicks, J. B. Shah, Arnold Reynaldi, N. Wilhausen, Wenzhao Meng, Sharon Adamski, S. Adamski, Scott Korte, E. Perkey
Publikováno v:
Science
SARS-CoV-2 mRNA vaccines have shown remarkable efficacy, especially in preventing severe illness and hospitalization. However, the emergence of several variants of concern and reports of declining antibody levels have raised uncertainty about the dur
Autor:
Rhonda Bassel-Duby, Efrain Sanchez-Ortiz, Richard J. Piercy, John M. Shelton, Eric N. Olson, Claire Massey, Hui Li, Alex A. Mireault, Thaleia-Rengina Stathopoulou, R. Harron, Daniel Caballero, Leonela Amoasii, John C. W. Hildyard
Publikováno v:
Science. 362:86-91
Gene editing and muscular dystrophy Duchenne muscular dystrophy (DMD) is characterized by progressive muscle weakness and a shortened life span. The disease is caused by mutations that reduce or prevent expression of dystrophin, an essential structur
Autor:
Ariel R. Weisman, Ajinkya Pattekar, Fang Chen, Caroline A. G. Ittner, Cécile Alanio, Sasikanth Manne, Zeyu Chen, E. John Wherry, Holly Ramage, M. Betina Pampena, Scott E. Hensley, Kito Nzingha, Justin Kim, Amy E. Baxter, Jeanette Dougherty, Divij Mathew, Michael R. Betts, Allison R. Greenplate, Claudia P. Arevalo, Yinghui Jane Huang, Leticia Kuri-Cervantes, Josephine R. Giles, Derek A. Oldridge, Nuala J. Meyer, Jennifer E. Wu, Marcus J. Bolton, Laura A. Vella, John P. Reilly, Alexander C. Huang, Elizabeth M. Anderson, Eileen C. Goodwin, Madison E. Weirick, Simon F. Lacey, Sokratis A. Apostolidis, Sara Cherry, Kurt D'Andrea, Nicholas Han, Sigrid Gouma, Oliva Kuthuru
Publikováno v:
Science
Science (New York, N.y.)
Science (New York, N.y.)
Immune profiling of COVID-19 patients Coronavirus disease 2019 (COVID-19) has affected millions of people globally, yet how the human immune system responds to and influences COVID-19 severity remains unclear. Mathew et al. present a comprehensive at
Autor:
Mark G. Lewis, Gabriel Dagotto, Frank Wegmann, Joseph P. Nkolola, Yuezhou Chen, Marinela Kirilova, Yongfei Cai, Jason Velasco, Catherine Jacob-Dolan, Shant H. Mahrokhian, John D. Ventura, Nicole Kordana, Esther A. Bondzie, Lisa H. Tostanoski, Felipe J.N. Lelis, Lauren Peter, Roland Zahn, Lori F. Maxfield, Elyse Teow, Makda S. Gebre, Laurent Pessaint, Jinyan Liu, Matthew D. Slein, Adam Zuiani, Ralph S. Baric, David R. Martinez, Bing Chen, John S. Burke, Alan Dodson, Duane R. Wesemann, Jingyou Yu, Xuan He, Brad Finneyfrock, Renita Brown, Alex Van Ry, Dan H. Barouch, Galit Alter, Katherine McMahan, Caroline Atyeo, Anthony Cook, Huahua Wan, Stephanie Fischinger, Aaron G. Schmidt, Kelvin Blade, Meghan Travers, Carolin Loos, Felix Nampanya, Zhenfeng Li, Ramya Nityanandam, Abishek Chandrashekar, Shaghayegh Habibi, Noe B. Mercado, Hanne Andersen, Zijin Lin
Publikováno v:
Science
Science (New York, N.y.)
Science (New York, N.y.)
The global coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has made the development of a vaccine a top biomedical priority. In this study, we developed a series of DNA vaccine candid