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Autor:
Christian Dienemann, Isaac Fianu, Olexandr Dybkov, Henning Urlaub, Ying Chen, Patrick Cramer, Andreas Linden
Publikováno v:
Science. 374:883-887
Integrator and protein phosphatase 2A (PP2A) form a complex that dephosphorylates paused RNA polymerase II (Pol II), cleaves the nascent RNA, and terminates transcription. We report the structure of the pretermination complex containing the human Int
Publikováno v:
Science. 374:347-351
Control by RNA polymerase II Evidence indicates that yeast cells initiate DNA synthesis and transition from the G 1 to the S phase of the cell cycle when cyclin 3 accumulates and causes phosphorylation of Whi5, a functional equivalent of the mammalia
Autor:
Seychelle M. Vos, Patrick Cramer, Dmitry E. Agafonov, Suyang Zhang, Shintaro Aibara, Reinhard Lührmann
Publikováno v:
Science
science
science
A tight couple makes messenger RNAs Gene expression in eukaryotes first requires transcription of DNA to an RNA copy and then splicing to form the final, processed messenger RNA (mRNA). Zhang et al. investigated how gene transcription and RNA splicin
Autor:
Hitoshi Kurumizaka, Mikako Shirouzu, Shun-ichi Sekine, Haruhiko Ehara, Yuka Fujino, Tomoya Kujirai
Publikováno v:
Science. 363:744-747
Getting over nucleosomal barriers In eukaryotic cells, RNA polymerase II (RNAPII) transcribes DNA within nucleosome-coated chromatin. The nucleosomes can provide major roadblocks for transcription. Cells solve this problem by using transcription elon
Autor:
Micca Hecht, Valentin Grube, Jan-Hendrik Spille, Charles H. Li, Ibrahim I Cisse, Choongman Lee, Won-Ki Cho
Publikováno v:
Science. 361:412-415
Phase separation and gene control Many components of eukaryotic transcription machinery—such as transcription factors and cofactors including BRD4, subunits of the Mediator complex, and RNA polymerase II—contain intrinsically disordered low-compl
Autor:
Deeba N. Syed, Asfa Ali, Jun Qi, Rajeev Sivasankaran, Graham S. Erwin, Mousheng Xu, Istaq Ahmad, Md. Ashraf, Asuka Eguchi, Matthew A. Lawlor, Deepak Kumar, Justin J. Jeffery, James E. Bradner, Katie A. Worringer, Aseem Z. Ansari, Anna McNally, Natalia Teider, Achal Kumar Srivastava, Paul M.C. Park, Matthew P. Grieshop, Hasan Mukhtar, Mohammed Faruq
Publikováno v:
Science. 358:1617-1622
Chemical control of transcription Friedreich's ataxia, a devastating neurodegenerative disease with no effective therapy, is caused by an expansion of intronic repeats and hence a reduced expression of the FXN gene. Erwin et al. synthesized a molecul
Autor:
Takeshi Yokoyama, Mikako Shirouzu, Shigeyuki Yokoyama, Shun-ichi Sekine, Haruhiko Ehara, Hideki Shigematsu
Publikováno v:
Science. 357:921-924
Transcription machinery remains steadfast Eukaryotic transcription of mRNA is a multistep process mediated by RNA polymerase II (Pol II). Pol II combines with several other factors to form an elongation complex that promotes transcription elongation.
Autor:
Di Jiang
Publikováno v:
Science. 372:1051.12-1053
Transcription As a critical transcription coactivator, the multisubunit Mediator complex binds RNA polymerase II (Pol II), facilitates preinitiation complex (PIC) assembly, and stimulates transcription and phosphorylation of the Pol II C-terminal dom
Autor:
Di Jiang
Publikováno v:
Science. 372:476.10-478
Transcription Eukaryotic transcription initiation by RNA polymerase II (Pol II) requires the assembly of a preinitiation complex (PIC) on core promoters. The binding of TATA box–binding protein (TBP) to the TATA box promoter has been thought to be
Autor:
Shinichiro Akichika, Seiichi Hirano, Yuichi Shichino, Takeo Suzuki, Hiroshi Nishimasu, Ryuichiro Ishitani, Ai Sugita, Yutaka Hirose, Shintaro Iwasaki, Osamu Nureki, Tsutomu Suzuki
Publikováno v:
Science. 363
INTRODUCTION N6-methyladenosine (m6A), an abundant modification in eukaryotic mRNAs and long-noncoding RNAs, has been recognized as a major epitranscriptome mark that plays critical roles in RNA metabolism and function. In addition to the internal m6