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Publikováno v:
RNA Biology. 18:2594-2604
Alternative polyadenylation (APA) is a widespread post-transcriptional modification method that changes the 3' ends of transcripts by altering poly(A) site usage. However, the longitudinal transcriptomic 3' end profile and its mechanism of action are
Autor:
Yuguang Zhao, Zhenyu Wang, Yi Liu, Shaokun Zhang, Zhigang Qu, Xinming Zhuang, Jiali Leng, Qingxu Song
Publikováno v:
RNA Biology. 18:2247-2260
MicroRNAs (miRNAs) are associated with healing or deteriorating degenerated intervertebral disc (IVD) tissues in spinal cord diseases, including intervertebral disc degeneration (IDD). IDD represen...
Autor:
Hannah Neiswender, Rajalakshmi Veeranan-Karmegam, Graydon B. Gonsalvez, Frederick C. Baker, Chandler H. Goldman, Saurav Misra
Publikováno v:
RNA Biol
The Dynein motor is responsible for the localization of numerous mRNAs within Drosophila oocytes and embryos. The RNA binding protein, Egalitarian (Egl), is thought to link these various RNA cargoes with Dynein. Although numerous studies have shown t
Publikováno v:
RNA Biol
The bacterial σ factor plays the central role in promoter recognition by RNA polymerase (RNAP). The primary σ factor, involved in transcription of housekeeping genes, was also shown to participate in the initiation of RNA synthesis and promoter esc
Publikováno v:
RNA Biology
article-version (VoR) Version of Record
article-version (VoR) Version of Record
MicroRNAs (miRNAs) play critical roles in gene expression and numerous human diseases. The success of miRNA biogenesis is largely determined by the primary miRNA (pri-miRNA) processing by the DROSHA-DGCR8 complex, called Microprocessor. Here, we anal
Publikováno v:
RNA Biol
Background Abnormal FTO expression causes faulty m6A modifications in mRNA and affects tumor progression. However, the expression and function of FTO in endometrial cancer (EC) and the genes regulated by FTO remain unclear.Methods qPCR detected the F
Autor:
Ana I. Garrido-Godino, Francisco Navarro, Francisco Gutiérrez-Santiago, Vicent Pelechano, José E. Pérez-Ortín, Alisa Alekseenko, A. B. Martinez-Padilla, Ishaan Gupta, Lars M. Steinmetz
Publikováno v:
RNA Biol
Gene expression involving RNA polymerase II is regulated by the concerted interplay between mRNA synthesis and degradation, crosstalk in which mRNA decay machinery and transcription machinery respectively impact transcription and mRNA stability. Rpb4
Autor:
Stephan F Bernhart, Elżbieta Boratyn, Peter F. Stadler, Jörg Fallmann, Iwona Nowak, Małgorzata Durbas, Sebastian Student, Hanna Rokita
Publikováno v:
RNA Biology
article-version (VoR) Version of Record
article-version (VoR) Version of Record
The role of the inflammation-silencing ribonuclease, MCPIP1 (monocyte chemoattractant protein-induced protein 1), in neoplasia continuous to emerge. The ribonuclease can cleave not only inflammation-related transcripts but also some microRNAs (miRNAs
Publikováno v:
RNA Biology. 18:988-998
The negative regulator of G-protein signalling 4 (Rgs4) is linked to several neurologic diseases, e.g. schizophrenia, addiction, seizure and pain perception. Consequently, Rgs4 expression is tightly regulated, resulting in high mRNA and protein turno
Autor:
Daniel B. Sloan, Jessica M. Warren, Thalia Salinas-Giegé, Joshua M. Svendsen, Laurence Maréchal-Drouard, Nicole L. Coots, Guillaume Hummel, Kristen C. Brown
Publikováno v:
RNA Biol
RNA Biology
RNA Biology, Taylor & Francis, 2020, pp.1-15. ⟨10.1080/15476286.2020.1792089⟩
RNA Biology
RNA Biology, Taylor & Francis, 2020, pp.1-15. ⟨10.1080/15476286.2020.1792089⟩
Differences in tRNA expression have been implicated in a remarkable number of biological processes. There is growing evidence that tRNA genes can play dramatically different roles depending on both expression and post-transcriptional modification, ye