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Autor:
Kimihiko Sugaya
Publikováno v:
RNA Biol
Mutations in molecules involved in transcription and splicing can cause chromosome instability such as sister chromatid exchanges. We isolated and characterized responsible genes from mammalian temperature-sensitive mutant cells showing chromosome in
Autor:
Nabeel S. Ganem, Ayelet T. Lamm
Publikováno v:
RNA Biology. 14:1690-1694
Adenosine-to-inosine RNA editing is a conserved process, which is performed by ADAR enzymes. By changing nucleotides in coding regions of genes and altering codons, ADARs expand the cell's protein repertoire. This function of the ADAR enzymes is esse
Publikováno v:
RNA Biology
RNA Biology, Taylor & Francis, 2017, 14 (12), pp.1637-1641. ⟨10.1080/15476286.2017.1343787⟩
RNA Biology, Taylor & Francis, 2017, 14 (12), pp.1637-1641. ⟨10.1080/15476286.2017.1343787⟩
Double-stranded RNA binding (DRB) proteins are generally considered as promoting cofactors of Dicer or Dicer-like (DCL) proteins that ensure efficient and precise production of small RNAs, the sequence-specificity guide of RNA silencing processes in
Publikováno v:
RNA Biology
Translation is fundamental for many biologic processes as it enables cells to rapidly respond to stimuli without requiring de novo mRNA synthesis. The mammalian/mechanistic target of rapamycin (mTOR) is a key regulator of translation. Although mTOR a
Autor:
Kunihiro Ohta, Naomichi Takemata
Publikováno v:
RNA Biology
Eukaryotic cells produce a variety of non-coding RNAs (ncRNAs), many of which have been shown to play pivotal roles in biological processes such as differentiation, maintenance of pluripotency of stem cells, and cellular response to various stresses.
Autor:
Scott Horowitz, James C.A. Bardwell
Publikováno v:
RNA Biology. 13:1228-1231
Recently, we found that RNA is a remarkably powerful chaperone that can bind to unfolded proteins and transfer them to Hsp70 for refolding. Combined with past studies on RNA-chaperone interactions, we propose a model for how chaperone RNA activity ma
Autor:
Iván D'Orso
Publikováno v:
RNA Biology. 13:545-553
RNA polymerase II (Pol II) pausing at promoter-proximal regions is a highly regulated step in the transcription cycle. Pause release is facilitated by the P-TEFb kinase, which phosphorylates Pol II and negative elongation factors. Recent studies sugg
Autor:
Murray P. Deutscher, Wenxing Liang
Publikováno v:
RNA Biology. 13:152-156
Repetitive Extragenic Palindromic (REP) sequences are highly conserved, structured, 35- to 40-nt elements located at ∼500 positions around the Escherichia coli chromosome. They are found in intergenic regions and are transcribed together with their