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Autor:
Yuguang Zhao, Zhenyu Wang, Yi Liu, Shaokun Zhang, Zhigang Qu, Xinming Zhuang, Jiali Leng, Qingxu Song
Publikováno v:
RNA Biology. 18:2247-2260
MicroRNAs (miRNAs) are associated with healing or deteriorating degenerated intervertebral disc (IVD) tissues in spinal cord diseases, including intervertebral disc degeneration (IDD). IDD represen...
Publikováno v:
RNA Biology
article-version (VoR) Version of Record
article-version (VoR) Version of Record
MicroRNAs (miRNAs) play critical roles in gene expression and numerous human diseases. The success of miRNA biogenesis is largely determined by the primary miRNA (pri-miRNA) processing by the DROSHA-DGCR8 complex, called Microprocessor. Here, we anal
Autor:
Stephan F Bernhart, Elżbieta Boratyn, Peter F. Stadler, Jörg Fallmann, Iwona Nowak, Małgorzata Durbas, Sebastian Student, Hanna Rokita
Publikováno v:
RNA Biology
article-version (VoR) Version of Record
article-version (VoR) Version of Record
The role of the inflammation-silencing ribonuclease, MCPIP1 (monocyte chemoattractant protein-induced protein 1), in neoplasia continuous to emerge. The ribonuclease can cleave not only inflammation-related transcripts but also some microRNAs (miRNAs
Publikováno v:
RNA Biology. 18:988-998
The negative regulator of G-protein signalling 4 (Rgs4) is linked to several neurologic diseases, e.g. schizophrenia, addiction, seizure and pain perception. Consequently, Rgs4 expression is tightly regulated, resulting in high mRNA and protein turno
Publikováno v:
RNA Biology. 16:770-784
miR-1246 is considered an oncomiR in various cancer types. However, the origin and biogenesis of miR-1246 remain controversial which often leads to misinterpretation of its detection and biological function, and inevitably masking its mechanisms of a
Autor:
Jianxun Wang, Xin Pang, Peifeng Li, Chang Liu, Zhuang Yu, Zhixia Zhou, Lichun Han, Zhijuan Lin, Xiang Ao, Murugavel Ponnusamy, Yuqi He
Publikováno v:
RNA Biology. 16:233-248
The development of chemotherapeutic drugs resistance such as doxorubicin (DOX) and cisplatin (DDP) is the major barrier in gastric cancer therapy. Emerging evidences reveal that microRNAs (miRNAs) contribute to chemosensitivity. In this study, we inv
Autor:
Eugene S. Kandel, Hannah Slabodkin, Amir B. Cohanim, Sydney Johnson, Leonid Brodsky, Peter Mechtler
Publikováno v:
RNA Biology. 14:1508-1513
MicroRNAs are short RNA molecules that regulate function and stability of a large subset of eukaryotic mRNAs. In the main pathway of microRNA biogenesis, a short "hairpin" is excised from a primary transcript by ribonuclease DROSHA, followed by addit