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Autor:
Fang Liu, Minqi Luo, Mingxia Wang, Xiaoxue Feng, Weixiang Peng, Zhaoxia Li, Shangling Zhu, Qiuxia Li, Jianlin Huang, Zhi-Ying Feng
Publikováno v:
Rheumatology. 54:1093-1102
OBJECTIVE The aim of this study was to investigate the expression of smoothened protein (Smo), a sonic hedgehog (Shh) signalling component, in synovium of RA and its role in the survival and apoptosis of endothelial cells. METHODS The expression of S
Autor:
Matthew Jefferson, Tim E. Cawston, M Elias, Gary J. Litherland, Wang Hui, Matt J. Barter, David Young, Andrew D. Rowan
Publikováno v:
Rheumatology. 49:2043-2053
Objectives To determine the effects and mechanism of action of lithium chloride (LiCl) on cartilage destruction induced by the pro-inflammatory cytokines IL-1, IL-1 + oncostatin M and TNF-α. Methods The release of collagen was assessed in bovine car
Autor:
Tim E. Cawston, Rachel L. Lakey
Publikováno v:
Rheumatology. 48:1208-1212
Objective To investigate the effect of SSZ on the release of GAG and collagen fragments from bovine nasal cartilage and MMP and ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin motifs) proteinases from human articular chondrocyt