Zobrazeno 1 - 10
of 94
pro vyhledávání: ''
Publikováno v:
Rheumatology. 61:1690-1698
Objectives To investigate whether physical activity interferes with joint homeostasis in the presence of distant inflammation originating at barrier tissues such as skin or gut. Methods Eight-week-old male C57/Bl6 mice were treated with imiquimod cre
Autor:
Alexander Hildebrandt, Serafeim Tsitsilonis, Johannes Keller, Anke Baranowsky, Jérôme Weber, Jessika Appelt, Denise Jahn, Tazio Maleitzke, Dario Zocholl, Tamara Elene Dietrich, Georg N. Duda
Publikováno v:
Rheumatology. 60:1996-2009
Objectives Calcitonin gene-related peptide alpha (αCGRP) represents an immunomodulatory neuropeptide implicated in pain perception. αCGRP also functions as a critical regulator of bone formation and is overexpressed in patients with rheumatoid arth
Autor:
Jianwei Li, Feng Huang, Shuai Liang, Shukuan Ling, Yuheng Li, Dengchao Cao, Caizhi Liu, Xiaoyan Jin, Gui Luo, Ruikai Du, Deqing Wang, Yiwen Wang, Xinxin Yuan, Yingxian Li, Zizhong Liu, Weijia Sun
Publikováno v:
Rheumatology. 59:1159-1169
Objective Bone loss is common in AS, and miR-214 plays an important role in regulating bone formation. The aim of this study was to investigate the effect of miR-214, the production of which is stimulated by IL-17A, on bone loss in AS. Methods Periph
Autor:
Takashi Yamashita, Ryosuke Saigusa, Takuya Miyagawa, Shinichi Sato, Yoshihide Asano, Megumi Hirabayashi, Shunsuke Miura, Takashi Taniguchi, Ayumi Yoshizaki, Maiko Fukayama, Kouki Nakamura, Takehiro Takahashi
Publikováno v:
Rheumatology. 59:2005-2015
ObjectivesAdipsin, or complement factor D, is a serine proteinase catalysing complement factor C3 breakdown, leading to the production of opsonin (C3b), membrane attack complex (C5b–C9) and anaphylatoxins (C3a and C5a). Since adipsin is potentially
Autor:
David G. I. Scott, Barbara M. Lund
Publikováno v:
Rheumatology. 60:5-7
Autor:
Romain Bordy, Céline Demougeot, Perle Totoson, Clément Prati, Frank Verhoeven, Daniel Wendling
Publikováno v:
Rheumatology. 58:1099-1103
OBJECTIVE To evaluate radiographic outcomes after an early treatment for 21 days with etanercept, naproxen, celecoxib, prednisone or methotrexate in adjuvant-induced arthritis in rats. METHODS At the onset of arthritis, rats were daily treated with n
Autor:
Paulo Louzada-Junior, Caio Cavalcante Machado, Alexandre Gomes de Macedo Maganin, Renê Donizeti Ribeiro de Oliveira, Sandra Y. Fukada, Tarcília Aparecida Silva, Thiago M. Cunha, Flávio P. Veras, F.F. Souza, José C. Alves-Filho, Lívia Corrêa Barroso, Fernando Q. Cunha, Ayda Henriques Schneider
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Objective To evaluate the role of neutrophil extracellular traps (NETs) in the genesis of joint hyperalgesia using an experimental model of arthritis and transpose the findings to clinical investigation. Methods C57BL/6 mice were subjected to antigen
Autor:
François Mineau, Jean-Pierre Pelletier, Ginette Tardif, Frédéric Paré, Johanne Martel-Pelletier, Bertrand Lussier, Gladys Valverde-Franco, Hassan Fahmi
Publikováno v:
Rheumatology. 57:1851-1860
Objective This study explored the role of the adipokine adipsin in OA. Methods Control and OA articular tissues, cells and serum were obtained from human individuals. Serum adipsin levels of human OA individuals were compared with cartilage volume lo
Publikováno v:
Rheumatology.
Objectives Knee OA is a leading global cause of morbidity. This study investigates the effects of knee SF from patients with OA on the activity of dorsal root ganglion sensory neurons that innervate the knee (knee neurons) as a novel translational mo
Autor:
Tatyana Vikulina, M. Neale Weitzmann, Meghan E. McGee-Lawrence, Kanglun Yu, Susanne Roser-Page
Publikováno v:
Rheumatology. 57:1105-1114
Objective Immunosuppressive biologics are used in the management of RA and additional immunomodulators are under investigation including modulators of the CD40/CD40 ligand (CD40L) costimulation pathway. Tampering with immune function can have unantic