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Autor:
Tim E. Cawston, Rachel L. Lakey
Publikováno v:
Rheumatology. 48:1208-1212
Objective To investigate the effect of SSZ on the release of GAG and collagen fragments from bovine nasal cartilage and MMP and ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin motifs) proteinases from human articular chondrocyt
Autor:
Ryuichi Gejo, Rie Katayama, Isao Matsushita, Noriyuki Tsumaki, S. Wakitani, Tomoatsu Kimura, Y. Morita
Publikováno v:
Rheumatology. 43:980-985
Objective. Cartilage-derived morphogenetic protein 1 (CDMP1), which is a member of the transforming growth factor-b superfamily, is an essential molecule for the aggregation of mesenchymal cells and acceleration of chondrocyte differentiation. In thi
Autor:
Ruud A. Bank, J. A. D. M. de Roos, Johan M. TeKoppele, F. C. Breedveld, Johan Hendrikus Verheijen, W.H. van der Laan, H.K. Ronday, Paul P. Tak, Christopher J. Froelich, Cornelis Erik Hack, Pancras C.W. Hogendoorn
Publikováno v:
Scopus-Elsevier
Rheumatology, 1, 40, 55-61
Rheumatology (Oxford, England), 40(1), 55-61. Oxford University Press
Rheumatology, 1, 40, 55-61
Rheumatology (Oxford, England), 40(1), 55-61. Oxford University Press
Objective. To investigate the cartilage-degrading capacity of granzyme B and the presence of granzyme B-positive cells at sites of erosion in the rheumatoid synovium. Methods. Granzyme B was added to [3H]proline/[35S]sulphate-labelled cartilage matri
Autor:
B A C Dijkmans, J. A. D. M. de Roos, R. A. Greenwald, H.K. Ronday, J. M. Te Koppele, Johan Hendrikus Verheijen, S. A. Moak, F. C. Breedveld
Publikováno v:
British journal of rheumatology, 1, 37, 34-38
The plasminogen activation system is one of the enzyme systems held responsible for bone and cartilage degradation in rheumatoid arthritis (RA). In this study, we evaluated the effect of tranexamic acid (TEA), an inhibitor of plasminogen activation,
Publikováno v:
Rheumatology. 35:828-838
We have developed a new model of autoimmune arthritis in DBA/1 mice by feeding chick type II collagen (CII) for 2-3 week intervals over a 15 week period. Clinically evident arthritis occurred in 8/10 mice receiving native CII (nCII; 100 micrograms/mo
Autor:
Pasquale Maffia, Kirsty Ross, Hannah E. Scales, Iain B. McInnes, Gordon R. Meiklejohn, Michelle Ierna, James M. Brewer, Karen M. Smith, Janet C. Patterson-Kane, Paul Garside
Publikováno v:
Rheumatology. :kev361
Objective. In the present study we evaluated the use of four commercially available fluorescent probes to monitor disease activity in murine CIA and its suppression during glucocorticoid therapy.\ud \ud Methods. Arthritis was induced in male DBA/1 mi
Autor:
R. A. Scudamore, T. D. V. Cooke
Publikováno v:
Rheumatology. 28:333-440
In this part we dwell on the damaging effect of immune reactions on joint tissues, also seeking explanations for the distinctive pattern of involvement of the joints, exemplified by changes in the hand