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Autor:
Andrea Savarino, Iart Luca Shytaj
Publikováno v:
Retrovirology
The restoration of the immune system prompted by antiretroviral therapy (ART) has allowed drastically reducing the mortality and morbidity of HIV infection. However, one main source of clinical concern is the persistence of immune hyperactivation in
Autor:
Rajarshi Guha, Lesley A. Mathews Griner, Kevin C. Conlon, Michiyuki Maeda, Meili Zhang, Wei Ju, Marc Ferrer, Michael N. Petrus, Thomas A. Waldmann, John J. O'Shea, Bernard Wen, Paul Shinn, Damien Y. Duveau, Craig J. Thomas, Richard N. Bamford
Publikováno v:
Retrovirology
Adult T-cell leukemia (ATL) develops in individuals infected with human T-cell lymphotropic virus-1 (HTLV-1). Presently there is no curative therapy for ATL. The HTLV-1-encoded protein Tax up-regulates Bcl-xL expression and constitutively activates i
Autor:
Kentro Yonekura, Koichiro Takeda, Yoshifusa Takatsuka, Ayumu Kubota, Nobuyo Kawakami, Syogo Takeuchi, Masahito Tokunaga, Nobuaki Nakano, Tamotsu Kanzaki, Atae Utsunomiya
Publikováno v:
Retrovirology
The novel defucosylated humanized monoclonal antibody against CC chemokine receptor 4 (CCR4), mogamulizumab, exhibited strong effects on adult T-cell leukemia-lymphoma (ATL) in a phase II clinical study. It has been also reported that mogamulizumab f
Publikováno v:
Retrovirology
The CC-chemokine receptor 4 (CCR4) is expressed in almost ATLL cells. Thus, anti-CCR4 antibodies can be used as a treatment strategy for ATLL. Mogamulizumab (MOG), which is a defucosylated anti-CCR4 monoclonal antibody, showed good results even in pa
Publikováno v:
Retrovirology
Adult T-cell leukemia/lymphoma (ATLL) is an aggressive malignancy with a poor prognosis caused by HTLV-I. Miami is proximal to the Caribbean, where HTLV-I is endemic. We have identified at least 140 cases between 1987 and 2013. A total of 108 patient
Autor:
Griselda Di Stefano, Ana Inés Varela, Andrea Mangano, Lilia Mammana, María Belén Bouzas, Liliana Olivares, María Saliba Pineda, Natalia Altamirano, Paula C. Aulicino, Luciana Tadey, Patricia Costantini, Cecilia Chidid, Luisa Sen
Publikováno v:
Retrovirology
Few ATLL cases have been reported in the country, the majority of the acute leukemia subtype. HTLV-1 proviral load is considered a prognosis marker and it has been available in our setting since 2008. We present HTLV-1 proviral loads in 3 cases of AT
Publikováno v:
Retrovirology
Adult T-cell leukemia-lymphoma (ATLL) is caused by HTLV-I, and is a disease with dismal prognosis urging new therapies. Brentuximab vedotin (SGN-35) is an anti-CD30 monoclonal antibody conjugated to a potent microtubule poisoning agent monomethyl aur
Autor:
Andrew Hodson, Maria-Antonietta Demontis, Charles R. M. Bangham, Lucy Cook, Anat Melamed, Graham P. Taylor, Nicolas Gillet
Publikováno v:
Retrovirology
The utility of HTLV-1 proviral load and integration site analysis by both a linker mediated PCR assay based on the Universal VectoretteTM System (Sigma Genosys) and by high through-put sequencing (HTPS) to assess the treatment response of four patien
Autor:
Maria Cd Fink, Guilherme Sciascia do Olival, José E. Vidal, Lenira Moraes, Laura Masami Sumita, Jorge Casseb, Augusto Cp de Oliveira, Camila Malta Romano, Luiz Hs Nali
Publikováno v:
Retrovirology
Multiple sclerosis (MS) is an inflammatory disorder of the central nervous system (CNS) and is the most common cause of neurological disability in young adults. MS-Associated Retrovirus (MSRV) is member of Human Endogenous Retroviruses W family, and
Publikováno v:
Retrovirology
Retrovirology, Vol 3, Iss Suppl 1, p P59 (2006)
Retrovirology, Vol 3, Iss Suppl 1, p P59 (2006)