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Autor:
Helen E. Ritchie, Elizabeth Hegedus, Dominqiue Abela, Andrew M. Howe, Emma Farrell, Deena Ababneh
Publikováno v:
Reproductive Toxicology. 106:109-114
Phenytoin is a known human teratogen with unknown etiology. Several mechanisms have been proposed including disturbances in folate metabolism, induction of embryonic hypoxia following phenytoin-induced bradycardia, free radical formation following re
Publikováno v:
Reproductive Toxicology. 104:16-26
Experimental models of maternal diabetes lead to the intrauterine programming of Gestational Diabetes Mellitus (GDM) in the offspring, together with an intrauterine proinflammatory environment, feto-placental metabolic alterations and fetal overgrowt
Publikováno v:
Reproductive Toxicology. 102:24-34
Testicular dysfunctions leading to male infertility has been reported in type 2 diabetes (T2D), with glucose dysmetabolism, cholinergic and purinergic dysfunction being major contributors. In the present study, the effect of vanillin on glucose metab
Publikováno v:
Reproductive Toxicology. 100:74-82
The panel of suitable reference genes in the fetal liver have not been reported. In this study, five commonly used reference genes (GAPDH, β-actin, Rn18 s, Rpl13a, and Rps29) were firstly selected as candidates. Bestkeeper, GeNorm, and NormFinder so
Publikováno v:
Reproductive Toxicology. 73:322-327
To confirm genetic variation in low-dose effects of diethylstilbestrol (DES), two inbred strains of rats, which have been selectively bred for high- and low-avoidance learning (HAA and LAA, respectively), were used in this study. LAA rats characteris
Autor:
Hiromichi Tamada, Aoi Ichikawa
Publikováno v:
Reproductive Toxicology. 63:62-69
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Reproductive Toxicology. 2016, 63, p.62-69
Article
Reproductive Toxicology. 2016, 63, p.62-69
Autor:
K. Minowa, L. Mutter, H. Matsuuchi, M. Glynn, H. Sanada, H. Okamura, W. Jo, H. Nejishima, Radhakrishnan Pillai
Publikováno v:
Reproductive Toxicology. 52:18-25
Efinaconazole is a new triazole antifungal for topical treatment of onychomycosis. The reproductive and developmental toxicity of efinaconazole was characterized in fertility and early embryonic development (rat), embryo-fetal development (rat and ra
Autor:
Hsiu Chu Chou, Chung Ming Chen
Publikováno v:
Reproductive Toxicology. 50:4-10
The aim of this study was to evaluate the effects of maternal nicotine exposure on heart morphology and fibrosis in rat offspring. Nicotine was administered to pregnant Sprague-Dawley rats by using a subcutaneous osmotic mini-pump at a dose of 6 mg/k
Safety profiles of gadolinium chelates in juvenile rats differ according to the risk of dissociation
Autor:
Meryam Maazouz, Cécile Factor, Marlène Rasschaert, Claire Corot, Gaëlle Jestin-Mayer, Fatiha Mecieb, Patrick Bruneval, Simon Bourgery, Nathalie Fretellier, Alexandrine Luseau, Fannie Baudimont, Jean-Marc Idée
Publikováno v:
Reproductive Toxicology. 50:171-179
This study was designed to compare the safety of two gadolinium chelates (GCs), used as contrast agents for magnetic resonance imaging, in juvenile rats. Juvenile rats received five intravenous administrations (between postnatal day [PND] 4 and 18) o
Publikováno v:
Reproductive Toxicology. 46:129-136
Embryonic exposure to excess circulating fuels is proposed to underlie diabetic embryopathy. To isolate the effects of hyperglycemia from the many systemic anomalies of diabetes, we infused 4 mg/min glucose into the left uterine artery of non-diabeti