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Publikováno v:
Reproductive Toxicology. 104:16-26
Experimental models of maternal diabetes lead to the intrauterine programming of Gestational Diabetes Mellitus (GDM) in the offspring, together with an intrauterine proinflammatory environment, feto-placental metabolic alterations and fetal overgrowt
Publikováno v:
Reproductive Toxicology. 100:74-82
The panel of suitable reference genes in the fetal liver have not been reported. In this study, five commonly used reference genes (GAPDH, β-actin, Rn18 s, Rpl13a, and Rps29) were firstly selected as candidates. Bestkeeper, GeNorm, and NormFinder so
Autor:
Vinay K. Khanna, Sanjay Mehrotra, Mukul Das, Bhushan P. Chaudhuri, Manjari Mishra, Shakir Ali, Vivek Mishra
Publikováno v:
Reproductive Toxicology. 40:24-34
Ovarian anomalies following oral oxytocin (OT) (1 and 10 ng/100 μl) exposure of female Wistar rat pups (10-day old) for 25 days was undertaken as OT injections are illegally used for milk let down in cattle thereby causing oral exposure to human pop
Publikováno v:
Reproductive Toxicology. 39:17-22
In our previous studies we described functional expression of organic cation transporter 3 (OCT3) and multidrug and toxin extrusion 1 (MATE1) protein in the rat placenta. Since metformin is a substrate of both OCT3 and MATE1, in this study we used th
Publikováno v:
Reproductive Toxicology. 34:378-384
The benzimidazole carbamate albendazole (ABZ), a potent anthelmintic, is a teratogenic compound in rats. At present it is unclear to which degree this effect is caused by the parent compound or its major metabolite, albendazole sulfoxide (ASO). Both
Autor:
Enrique H. Luque, Mónica Muñoz-de-Toro, Gabriela A. Altamirano, Laura Kass, Verónica L. Bosquiazzo
Publikováno v:
Reproductive Toxicology. 33:390-400
The current study examined the consequences of perinatal (gestation + lactation) exposure to Bisphenol A (BPA) or diethylstilbestrol (DES) on F1 mammary gland (MG) differentiation. BPA (0, 0.7 or 64 μg/kg bw/day) or DES (6 μg/kg bw/day) was adminis
Publikováno v:
Reproductive Toxicology. 28:46-51
Placental 11 beta-hydroxysteroid dehydrogenase type 2 (11 beta-HSD2) is the key enzyme which protects the fetus from overexposure to glucocorticoids (GCs) by their oxidation into inactive derivates. Several recent studies suggest that 11 beta-HSD2 ex
Publikováno v:
Reproductive Toxicology. 27:177-185
Triclosan (TCS), a chlorophenol, is widely used as a preservative in different types of commercial preparations. The reports on TCS-mediated endocrine disruption are controversial and the present study aimed to elucidate the probable mode of action o
Autor:
Myung Sook Oh, Seong Kyu Park, Hyunsu Bae, Do Rim Kim, Mun Seog Chang, Wansu Park, Youngbuhm Huh
Publikováno v:
Reproductive Toxicology. 24:365-370
A side effect of cyclophosphamide (CP), an alkylating agent widely used to treat tumors and autoimmune disorders, is the alteration of male reproductive function. Yukmijihwang-tang (YJT) is a multi-herbal medicinal formula that has been used in tradi
Publikováno v:
Reproductive Toxicology. 23:226-231
The aims of this study were to investigate the effects of homocysteine (Hcy) on epididymal sperm characteristics, plasma testosterone level and biochemical changes related to oxidative stress and to examine the effects of melatonin (Mlt) or Vitamin E