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Autor:
Vinay K. Khanna, Sanjay Mehrotra, Mukul Das, Bhushan P. Chaudhuri, Manjari Mishra, Shakir Ali, Vivek Mishra
Publikováno v:
Reproductive Toxicology. 40:24-34
Ovarian anomalies following oral oxytocin (OT) (1 and 10 ng/100 μl) exposure of female Wistar rat pups (10-day old) for 25 days was undertaken as OT injections are illegally used for milk let down in cattle thereby causing oral exposure to human pop
Autor:
Leonardo O. Mendes, Beatriz Aparecida Fioruci-Fontanelli, Francisco Eduardo Martinez, Fábio Rodrigues Ferreira Seiva, Marcelo Martinez, Wagner José Fávaro, Patricia Fernanda Felipe Pinheiro, João Paulo de Arruda Amorim, Luiz Gustavo de Almeida Chuffa, Giovana Rampazzo Teixeira
Publikováno v:
Reproductive Toxicology. 39:40-49
Chronic ethanol intake is associated with sex hormone disturbances, and it is well known that melatonin plays a key role in regulating several reproductive processes. We report the effects of ethanol intake and melatonin treatment (at doses of 100 μ
Publikováno v:
Reproductive Toxicology. 34:708-719
Environmental compounds are known to promote epigenetic transgenerational inheritance of disease. The current study was designed to determine if a “pesticide mixture” (pesticide permethrin and insect repellent N,N-Diethyl-meta-toluamide, DEET) pr
Publikováno v:
Reproductive Toxicology. 28:556-562
Cisplatin administration for treatment of cancer causes damage to the ovaries, potentially leading to ovarian failure. To extend our previous work, we tested the hypothesis that serum anti-Mullerian hormone (AMH) levels after ovarian stimulation can
Publikováno v:
Reproductive Toxicology. 15:215-219
Lithium chloride, a compound with clinical use in bipolar disorder, produces adverse effects on ovarian function in amphibian and rodent models. This study examined the effect of human chorionic gonadotrophin coadministration on ovarian steroidogenic
Publikováno v:
Reproductive Toxicology. 14:247-255
Immature rats were treated with estradiol cypionate, (ECP, 0, 0.1, 1, or 2 mg/kg s.c.) followed 24 h later by TCDD (0 or 10 microg/kg orally). Follicular development was induced with eCG [5 or 10 IU subcutaneously (s.c.)] followed by an ovulatory dos
Publikováno v:
Reproductive Toxicology. 12:217-221
Raloxifene is a nonsteroidal, selective estrogen receptor modulator being developed by Eli Lilly and Company as a therapeutic agent for postmenopausal osteoporosis. In the ovariectomized (OVX) rat, raloxifene prevents the loss of bone at the distal m
Publikováno v:
Reproductive Toxicology. 11:185-190
Dithiocarbamates, acting as inhibitors of catecholamine synthesis, have been reported to block ovulation in female rats following systemic administration by suppressing the neural noradrenergic signaling involved in triggering the ovulatory surge of
Autor:
John W. Laskey, Ezra Berman
Publikováno v:
Reproductive Toxicology. 7:349-358
Cultures of minced, whole-ovary (whole-ovary culture) were used to determine if three selected chemicals altered steroidogenic profiles. First, phenolsulfonthalein (PST), when used in culture medium, was tested for its influence on in vitro steroidog
Publikováno v:
Reproductive Toxicology. 7:131-135
The null hypothesis of this study was that the angiotensin-converting enzyme inhibitors, captopril and teprotide, would not reduce the number of ovulations in vivo and in vitro in the rat. Captopril (in three regimens) was administered continuously b