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Publikováno v:
Reproductive Toxicology. 102:24-34
Testicular dysfunctions leading to male infertility has been reported in type 2 diabetes (T2D), with glucose dysmetabolism, cholinergic and purinergic dysfunction being major contributors. In the present study, the effect of vanillin on glucose metab
Autor:
Hsiu Chu Chou, Chung Ming Chen
Publikováno v:
Reproductive Toxicology. 50:4-10
The aim of this study was to evaluate the effects of maternal nicotine exposure on heart morphology and fibrosis in rat offspring. Nicotine was administered to pregnant Sprague-Dawley rats by using a subcutaneous osmotic mini-pump at a dose of 6 mg/k
Safety profiles of gadolinium chelates in juvenile rats differ according to the risk of dissociation
Autor:
Meryam Maazouz, Cécile Factor, Marlène Rasschaert, Claire Corot, Gaëlle Jestin-Mayer, Fatiha Mecieb, Patrick Bruneval, Simon Bourgery, Nathalie Fretellier, Alexandrine Luseau, Fannie Baudimont, Jean-Marc Idée
Publikováno v:
Reproductive Toxicology. 50:171-179
This study was designed to compare the safety of two gadolinium chelates (GCs), used as contrast agents for magnetic resonance imaging, in juvenile rats. Juvenile rats received five intravenous administrations (between postnatal day [PND] 4 and 18) o
Publikováno v:
Reproductive Toxicology. 34:443-450
This study investigated the effects of antipsychotic drugs on heart function of gestational day (GD) 13 rat embryos in vitro since they all block the IKr/hERG potassium ion channel in addition to their main pharmacological effect on neurotransmitters
Publikováno v:
Reproductive Toxicology. 28:556-562
Cisplatin administration for treatment of cancer causes damage to the ovaries, potentially leading to ovarian failure. To extend our previous work, we tested the hypothesis that serum anti-Mullerian hormone (AMH) levels after ovarian stimulation can
Autor:
Akiyoshi Nishikawa, Masao Hirose, Makoto Shibutani, Gye-Hyeong Woo, Miwa Takahashi, Hitoshi Fujimoto, Yukie Saegusa, Kaoru Inoue
Publikováno v:
Reproductive Toxicology. 28:297-307
To clarify the developmental effects of hypothyroidism and to establish a detection system of resultant brain retardation, pregnant rats were administered 3 or 12 ppm of 6-propyl-2-thiouracil (PTU) or 200 ppm of methimazole (MMI) in the drinking wate
Publikováno v:
Reproductive Toxicology. 28:46-51
Placental 11 beta-hydroxysteroid dehydrogenase type 2 (11 beta-HSD2) is the key enzyme which protects the fetus from overexposure to glucocorticoids (GCs) by their oxidation into inactive derivates. Several recent studies suggest that 11 beta-HSD2 ex
Publikováno v:
Reproductive Toxicology. 23:226-231
The aims of this study were to investigate the effects of homocysteine (Hcy) on epididymal sperm characteristics, plasma testosterone level and biochemical changes related to oxidative stress and to examine the effects of melatonin (Mlt) or Vitamin E
Publikováno v:
Reproductive Toxicology. 21:54-59
Adriamycin (ADR), an anthracycline antibiotic, which is widely used as an antineoplastic drug in the treatment of various solid tumors, has been shown to induce reproductive abnormalities in males. In the present study, the effect of lipoic acid (LA)
Autor:
Guy Mazue, Debora Manera, Jacqueline Lansen, Paolo Colombo, Monica Longo, Sara Zanoncelli, Piero Olliaro, Walter R. J. Taylor, Marco Brughera, Melba Gomes
Publikováno v:
Reproductive Toxicology. 21:83-93
Artemisinin derivatives are not currently recommended for use during the first trimester of pregnancy because they cause embryo death and some abnormalities in early pregnancy in animals. We studied the effects of dihydroartemisinin (DHA) in rat whol