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Autor:
Janine M. Davies, Dimitri G. Trembath, William K. Funkhouser, Allison M. Deal, Timothy Finnegan, Bert H. O'Neil, Joel E. Tepper, Karen E. Weck, Benjamin F. Calvo
Publikováno v:
Radiation Oncology (London, England)
Radiation Oncology, Vol 6, Iss 1, p 114 (2011)
Radiation Oncology, Vol 6, Iss 1, p 114 (2011)
Background KRAS mutations may predict poor response to radiotherapy. Downstream events from KRAS, such as activation of BRAF, AKT and ERK, may also confer prognostic information but have not been tested in rectal cancer (RC). Our objective was to exp
Autor:
Bingqiang Hu, Xiaoxue Xie, Yingying Zhang, H. Jin, Junming Luo, Xuping Xi, Jun Hu, Shuyu Ouyang, Hui Wang, Jumei Zhou
Publikováno v:
Radiation Oncology (London, England)
Background Codon 72 (Arg/Pro), the most frequently studied single nucleotide polymorphism (SNP) of p53 to date, is associated with the ability of the gene to induce cell apoptosis. The PI3K/Akt pathway plays an essential role in the transcriptional a
Autor:
Thomas W. Flaig, Tracey E. Schefter, Michelle A. Stinauer, Michael Glode, David Raben, Karl D. Lewis, Mark Chidel, William A. Robinson, Brian D. Kavanagh, Rene Gonzalez
Publikováno v:
Radiation Oncology (London, England)
Radiation Oncology, Vol 6, Iss 1, p 34 (2011)
Radiation Oncology, Vol 6, Iss 1, p 34 (2011)
Background Melanoma and renal cell carcinoma (RCC) are traditionally considered less radioresponsive than other histologies. Whereas stereotactic body radiation therapy (SBRT) involves radiation dose intensification via escalation, we hypothesize SBR
Autor:
Hiroko Kuwabara, Erina Yoritsune, Tomo Miyata, Toshihiko Kuroiwa, Shinji Kawabata, Motomasa Furuse, Taichiro Toho, Naosuke Nonoguchi, Shin-Ichi Miyatake
Publikováno v:
Radiation Oncology (London, England)
Background Brain radiation necrosis (RN) occurring after radiotherapy is a serious complication. We and others have performed several treatments for RN, using anticoagulants, corticosteroids, surgical resection and bevacizumab. However, the mechanism