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Publikováno v:
Psychopharmacology. 233:2727-2736
Activation of corticotropin-releasing factor type 1 receptors (CRF-R1) in the ventral tegmental area (VTA) represents a critical mechanism for social defeat to escalate cocaine self-administration in adult rats.We determined the acute effect of a CRF
Publikováno v:
Psychopharmacology. 228:623-631
Stress has been shown to be a significant factor in the maintenance of marijuana use. Oxytocin is a hypothalamic neuropeptide that has been shown to moderate behavioral responding to stress as well as play a role in the neuroadaptations that occur as
Autor:
James M. Doherty, Kyle J. Frantz
Publikováno v:
Psychopharmacology. 225:595-604
Early onset of heroin use during adolescence might increase chances of later drug addiction. Prior work from our laboratory suggests, however, that adolescent male rats are actually less sensitive than adults to some enduring effects of heroin self-a
Autor:
Sherry A. McKee, Christopher W. Kahler, Damaris J. Rohsenow, Valerie S. Knopik, Jane Metrik, Nichea S. Spillane, Jennifer W. Tidey, John E. McGeary, Adam M. Leventhal
Publikováno v:
Psychopharmacology. 222:71-80
Alcohol use is often implicated in initial lapses to smoking during quit smoking attempts. Mechanisms explaining this association are unknown but could include (a) learned associations between drinking and smoking or (b) direct pharmacologic effects
Autor:
Paul S. Horn, Brad Chambers, Jon F. Davis, Rebecca Ahlbrand, Neil M. Richtand, Stephen C. Benoit
Publikováno v:
Psychopharmacology. 222(2)
Addiction is a disease of learning and memory, as learning processes underlying acquisition, extinction, and reinstatement of drug-paired associations play central roles in addiction. Early developmental stress enhances risk for drug problems in adul