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Autor:
Satoshi Ishido, Andrew I. Webb, Nadia J. Kershaw, Warren S. Alexander, Jarrod J. Sandow, Nicos A. Nicola, Cyrus Tan, Douglas J. Hilton, Jeffrey J. Babon, Dina Stockwell
Publikováno v:
PROTEOMICS. 21:2000244
MARCH proteins are membrane-associated Ring-CH E3 ubiquitin ligases that dampen immune responses by downregulating cell surface expression of major histocompatibility complexes I and II as well as immune co-stimulatory receptors. We recently showed t
Publikováno v:
Proteomics. 18(13)
Cardiac fibroblasts (CFs) are one of the main cell populations in the heart and play important roles in tissue homeostasis and myocardial fibrosis. The study of these cells has been hampered by the lack of reliable membrane markers: none of the antig
Publikováno v:
PROTEOMICS. 12:3559-3579
While the mechanisms that underpin maturation, capacitation, and sperm-egg interactions remain elusive it is known that these essential fertilisation events are driven by the protein complement of the sperm surface. Understanding these processes is c
Autor:
James E. Bruce
Publikováno v:
PROTEOMICS. 12:1565-1575
Proteins are a remarkable class of molecules that exhibit wide diversity of shapes or topological features that underpin protein interactions and give rise to biological function. In addition to quantitation of abundance levels of proteins in biologi
Publikováno v:
PROTEOMICS. 11:2377-2388
Proteases are critical in many physiological processes and the human genome encodes for 566 predicted proteolytic enzymes. Therefore, there is great interest in identifying and characterizing physiologic protease-substrate relationships. The coagulat
Autor:
Zhe Jenny Zhang, Scott C. Peck
Publikováno v:
PROTEOMICS. 11:1780-1788
The plasma membrane (PM) serves as the point of contact between cells and the outside environment. As such, changes in the PM proteome are an important component of understanding cellular responses to a diverse array of stimuli. However, intricate sa
Publikováno v:
PROTEOMICS. 10:4053-4076
Lysosomes are organelles of eukaryotic cells that are critically involved in the degradation of macromolecules mainly delivered by endocytosis and autophagocytosis. Degradation is achieved by more than 60 hydrolases sequestered by a single phospholip
Publikováno v:
PROTEOMICS. 10:1141-1149
Membrane proteins are key molecules in the cell, and are important targets for pharmaceutical drugs. Few three-dimensional structures of membrane proteins have been obtained, which makes computational prediction of membrane proteins crucial for studi
Autor:
Andreas Peschel, Christoph M. Ernst, Susanne Sievers, Tobias Geiger, Christiane Wolz, Dörte Becher, Michael Hecker
Publikováno v:
PROTEOMICS. 10:1685-1693
The dynamic lipid composition of bacterial cytoplasmic membranes has a profound impact on vital bacterial fitness and susceptibility to membrane-damaging agents, temperature, or osmotic stress. However, it has remained largely unknown how changes in
Autor:
Chii-Shiarng Chen, Chi-Yu Lu, Wan-Nan Uang Chen, Li-Hsueh Wang, Lee-Shing Fang, Yu-Bao Wang, Shao-En Peng
Publikováno v:
PROTEOMICS. 10:1002-1016
Symbiosomes are specific intracellular membrane-bound vacuoles containing microalgae in a mutualistic Cnidaria (host)-dinoflagellate (symbiont) association. The symbiosome membrane is originally derived from host plasma membranes during phagocytosis