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Autor:
James Clifton, Djuro Josic
Publikováno v:
PROTEOMICS. 7:3010-3029
Plasma membrane proteins serve essential functions for cells, interacting with both cellular and extracellular components, structures and signaling molecules. Additionally, plasma membrane proteins comprise more than two-thirds of the known protein t
Publikováno v:
Proteomics. 15(19)
Ecto-protein kinases phosphorylate extracellular membrane proteins and exhibit similarities to casein kinases and protein kinases A and C. However, the identification of their protein substrates still remains a challenge because a clear separation fr
Autor:
Bettina Schmid, Peer-Hendrik Kuhn, Frauke van Bebber, Bastian Dislich, Christian Haass, Stefan F. Lichtenthaler, Sebastian Hogl
Publikováno v:
Practical proteomics 13(9), 1519-1527 (2013). doi:10.1002/pmic.201200582
The aspartyl protease BACE1 cleaves neuregulin 1 and is involved in myelination and is a candidate drug target for Alzheimer's disease, where it acts as the β-secretase cleaving the amyloid precursor protein. However, little is known about other sub
Autor:
Ju-Yong Park, So Young Chun, Mi-Hyun Ha, Je-Yong Choi, Je-Yeol Cho, Tae-Ho Kim, Byung Geun Ha, Shin-Yoon Kim, Jung Min Hong, Hong-In Shin, Hyun-Mo Ryoo, Eui Kyun Park
Publikováno v:
Proteomics. 8(13)
Osteoclast formation and bone resorption are multiple processes that involve the participation of specialized membrane structures and their associated proteins. In this study, we used an MS to analyze the profile of proteins associated with osteoclas
Autor:
Yong-Yang Wu, Ming-Li Yang, Lijuan Chen, Xin-Yu Liu, Yuquan Wei, Shufang Liang, Ying Zhang, Minghai Tang, Jinliang Yang, Fu-Qiang Li
Publikováno v:
Proteomics. 8(3)
In temporal lobe epilepsy (TLE), the seizure origin typically involves the hippocampal formation. The pilocarpine-induced TLE provides a model to investigate the molecular and functional characterization of epileptogenesis by mimicking the human epil