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Autor:
James Clifton, Djuro Josic
Publikováno v:
PROTEOMICS. 7:3010-3029
Plasma membrane proteins serve essential functions for cells, interacting with both cellular and extracellular components, structures and signaling molecules. Additionally, plasma membrane proteins comprise more than two-thirds of the known protein t
Autor:
Bettina Schmid, Peer-Hendrik Kuhn, Frauke van Bebber, Bastian Dislich, Christian Haass, Stefan F. Lichtenthaler, Sebastian Hogl
Publikováno v:
Practical proteomics 13(9), 1519-1527 (2013). doi:10.1002/pmic.201200582
The aspartyl protease BACE1 cleaves neuregulin 1 and is involved in myelination and is a candidate drug target for Alzheimer's disease, where it acts as the β-secretase cleaving the amyloid precursor protein. However, little is known about other sub
Autor:
Yong-Yang Wu, Ming-Li Yang, Lijuan Chen, Xin-Yu Liu, Yuquan Wei, Shufang Liang, Ying Zhang, Minghai Tang, Jinliang Yang, Fu-Qiang Li
Publikováno v:
Proteomics. 8(3)
In temporal lobe epilepsy (TLE), the seizure origin typically involves the hippocampal formation. The pilocarpine-induced TLE provides a model to investigate the molecular and functional characterization of epileptogenesis by mimicking the human epil