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Autor:
Satoshi Ishido, Andrew I. Webb, Nadia J. Kershaw, Warren S. Alexander, Jarrod J. Sandow, Nicos A. Nicola, Cyrus Tan, Douglas J. Hilton, Jeffrey J. Babon, Dina Stockwell
Publikováno v:
PROTEOMICS. 21:2000244
MARCH proteins are membrane-associated Ring-CH E3 ubiquitin ligases that dampen immune responses by downregulating cell surface expression of major histocompatibility complexes I and II as well as immune co-stimulatory receptors. We recently showed t
Publikováno v:
Proteomics. 18(13)
Cardiac fibroblasts (CFs) are one of the main cell populations in the heart and play important roles in tissue homeostasis and myocardial fibrosis. The study of these cells has been hampered by the lack of reliable membrane markers: none of the antig
Publikováno v:
PROTEOMICS. 10:1141-1149
Membrane proteins are key molecules in the cell, and are important targets for pharmaceutical drugs. Few three-dimensional structures of membrane proteins have been obtained, which makes computational prediction of membrane proteins crucial for studi
Publikováno v:
PROTEOMICS. 8:4733-4747
The molecular mechanisms controlling the progression of melanoma from a localized tumor to an invasive and metastatic disease are poorly understood. In the attempt to start defining a functional protein profile of melanoma progression, we have analyz
Autor:
Toshinori Nakayama, Masaru Taniguchi, Jun Nagafune, Atsushi Hinohara, Yasunori Yamaguchi, Hiroshi Watarai
Publikováno v:
PROTEOMICS. 5:4001-4011
The differential expression of surface molecules on dendritic cells (DC) reflects their functional differences as immature and mature subsets. It is difficult, however, to characterize differences in surface expression by standard proteomic approache
Autor:
Richard J. Simpson, Suresh Mathivanan
Publikováno v:
Proteomics. 9(21)
Exosomes, membrane microvesicles (40-100 nm) secreted by most cell types, can be isolated in several ways while characterizing them is heavily based on electron microscopy and, most importantly, the identification of exosome marker proteins. Research
Autor:
Jun Ho Jang, Samir M. Hanash
Publikováno v:
Proteomics. 3(10)
The in depth-mining of the proteome necessitates the comprehensive analysis of proteins in individual subcellular compartments to uncover interesting patterns of protein expression that include assessment of protein location, trafficking and of post-