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Autor:
Bárbara Du-Rocher, Luciana Pizzatti, Julliana Ferreira Sant’Anna, Milene Rangel da Costa, Eliana Abdelhay, Adalberto Vieyra, Rafael Soares Lindoso
Publikováno v:
PROTEOMICS. 14:1480-1493
Acute kidney injury (AKI) is one of the more frequent and lethal pathological conditions seen in intensive care units. Currently available treatments are not totally effective but stem cell-based therapies are emerging as promising alternatives, espe
Publikováno v:
Proteomics
Tropomyosin-related kinase A (TrkA) is a receptor-type protein tyrosine kinase and exploits pleiotypic roles via nerve growth factor (NGF)-dependent or NGF-independent mechanisms in various cell types. Here, we showed that the inhibition of TrkA acti
Autor:
Qingsong Lin, Ping Chen, Canhua Huang, Quek Choon Lau, Jiong Li, Aiping Tong, Lijuan Chen, Yuquan Wei, Xia Zhao, Lihong Wu, Hong Tang
Publikováno v:
PROTEOMICS. 8:2012-2023
Hepatitis B virus (HBV) is one of the major etiological factors responsible for acute and chronic liver disease and for the development of hepatocellular carcinoma (HCC). To determine the effects of HBV replication on host cell-protein expression, we
Autor:
Lili Li, Wei Luo, Min Tang, Guangrong Yan, Yongguang Tao, Yong Wu, Zigang Dong, Ya Cao, Yi-ping Liu, Sufang Liu
Publikováno v:
PROTEOMICS. 6:1810-1821
Previous studies have shown that the Epstein-Barr virus-encoded latent membrane protein1 (LMP1) could activate nuclear factor kappa B, activator protein-1, and Janus kinases/signal transducer and activation of transcription factors pathways. However,
Autor:
James D. Pomonis, Gregory F. Egnaczyk, John E. Maggio, Joseph R. Ghilardi, Julie A Schmidt, Patrick W. Mantyh, Christopher M. Peters, Scott D. Rogers
Publikováno v:
PROTEOMICS. 3:689-698
Reactive gliosis is an invariant feature of the pathology of central nervous system (CNS) injury and a major determinant of neuronal survival and regeneration. To begin to understand the alterations in astrocyte protein expression that drive glial ch
Publikováno v:
PROTEOMICS. 1:767-772
The interferons and interleukin-6 (IL-6) family cytokines exert their biological effects via Janus kinase and signal transducer and activator of transcription (JAK-STAT) signalling pathways. Our aim is to identify "novel" signalling molecules not pre
Autor:
Harald Höger, Jun-Fang Zheng, Lin Li, Gert Lubec, Gunyong An, Sudarshan Patil, Sanjay V. Boddul
Publikováno v:
Proteomics. 11(18)
Studying fear extinction is a major topic in neuroscience. No information on systematic studies on the linkage of contextual fear conditioning (cFC) with hippocampal protein levels is available and we were therefore interested in protein differences
Publikováno v:
Proteomics. 8(15)
The transcription factor Forkhead box L subfamily member 2 (FOXL2) is involved in craniofacial development and ovarian function. Using 2-DE and immunoblotting, we show that it is highly modified post-translationally. The most outstanding feature of i
Autor:
Sylvie Poussard, Elise Dargelos, Stéphane Claverol, Marc Bonneu, Patrick Cottin, Sébastien Goudenege
Publikováno v:
Proteomics. 7(18)
Caveolae are specialised RAFTs (detergent-resistant membrane microdomains enriched in cholesterol and glycosphingolipids). Caveolin, the main caveolae protein, is essential to the organisation of proteins and lipids, and interacts with numerous media
Autor:
Alberto Bavelloni, Irene Faenza, Lucio Cocco, Daniela Parisi, Manuela Piazzi, Nadir M. Maraldi, Ivan Matic, Gabriella Cioffi
Publikováno v:
Proteomics
An extensive body of evidence links inositide-specific phospholipase C (PLC) to the nucleus and the main isoform located in the nucleus is PLCbeta(1). Constitutive overexpression of nuclear PLCbeta(1) has been previously shown to inhibit Friend eryth