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Autor:
Chantragan Srisomsap, Kriengsak Lirdprapamongkol, Pantipa Subhasitanont, Daranee Chokchaichamnankit, Dumnoensun Pruksakorn, Jisnuson Svasti, Khajeelak Chiablaem
Publikováno v:
PROTEOMICS. 10:3896-3904
3-D cell culture models are important in cancer biology since they provide improved understanding of tumor microenvironment. We have established a 3-D culture model using HepG2 in natural collagen-based scaffold to mimic the development of small avas
Autor:
Rosamonde E. Banks, Sarah Hanrahan, James Dods, Nick Totty, Anthea J. Stanley, Richard D. Unwin, Patricia Harnden, Ian Eardley, Rachel A. Craven, Peter Selby
Publikováno v:
PROTEOMICS. 6:2853-2864
New markers/targets for renal cell carcinoma (RCC) are needed to enable earlier detection and monitoring of disease and therapeutic targeting. To identify such molecules, normal and RCC-derived primary cell lines have been used as a simplified model
Autor:
Nicola Esposito, Francesco Salvatore, Irene Colavita, Concetta Quintarelli, Ersilia Nigro, Margherita Ruoppolo, Fabrizio Pane
Publikováno v:
Proteomics. 13(16)
In the present study, we used a functional proteomic approach to identify Annexin A1 (Anxa1) interacting proteins in the Philadelphia-positive KCL22 cell line. We focused on Anxa1 because it is one of the major proteins upregulated in imatinib-sensit
Autor:
Tim Koppen, Tilo Schwientek, Stefan Müller, Andreas Weckmann, Simon Staubach, Wilhelm Bloch, R. Jürgen Dohmen
Publikováno v:
Proteomics. 11(22)
Distinct types of vesicles are formed in eukaryotic cells that conduct a variable set of functions depending on their origin. One subtype designated circulating microvesicles (MVs) provides a novel form of intercellular communication and recent work
Autor:
Deborah Trott, Ciara A. McManus, Michael J. Dunn, Marlene L. Rose, Jody L. Martin, Bryony Brennan
Publikováno v:
Proteomics. 9(12)
Recent studies have suggested a protective role of hsp27 against atherosclerosis and transplant graft vasculopathy. Here we have investigated the effects of over-expression of wild-type hsp27 and its phosphorylation mimics on proliferation of human e