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Autor:
Bettina Schmid, Peer-Hendrik Kuhn, Frauke van Bebber, Bastian Dislich, Christian Haass, Stefan F. Lichtenthaler, Sebastian Hogl
Publikováno v:
Practical proteomics 13(9), 1519-1527 (2013). doi:10.1002/pmic.201200582
The aspartyl protease BACE1 cleaves neuregulin 1 and is involved in myelination and is a candidate drug target for Alzheimer's disease, where it acts as the β-secretase cleaving the amyloid precursor protein. However, little is known about other sub