Zobrazeno 1 - 10
of 85
pro vyhledávání: ''
Autor:
Edward J. Messina, Terry O. Myers
Publikováno v:
Prostaglandins. 52:415-430
We examined the contribution of prostaglandins to altered reactivity to norepinephrine in rat cremaster third order arterioles of streptozotocin (STZ) treated rats and age-matched controls. NE was applied topically to the cremaster muscle of pentobar
Publikováno v:
Prostaglandins. 51:331-338
We investigated the effect of oral administration of CuNSN, a bis(2-benzimidazolyl) thioether (see structure 1) on gastric lesions induced in rats by acetylsalicylic acid (ASA) or ethanol. The involvement of endogenous eicosanoids and nitric oxide in
Publikováno v:
Prostaglandins. 40:445-461
N-methyl LTC4 (NMLTC4) a synthetic analogue of LTC4, has been shown not to be a substrate for gamma-glutamyl transpeptidase. NMLTC4 produced contractions of the guinea pig ileum and trachea with pD2 values of 7.7 +/- 0.12 (n = 6) and 8.1 +/- 0.1 (n =
Publikováno v:
Prostaglandins. 53(4)
We examined whether beraprost sodium (beraprost), a stable analogue of PGI2, has an anti-inflammatory effect on the permeability barrier through endothelial cells in vivo. The injection of collagen (5 micrograms/head) plus epinephrine (0.6 microgram/
Publikováno v:
Prostaglandins. 53(1)
Prostaglandins (PGs) affect various aspects of gastric functions. In the present study the orally administered PGI 2 derivative beraprost sodium (TRK-100, I μg per kg body weight) decreased oxyntic histidine decarboxylase activity without changing s
Publikováno v:
Prostaglandins. 52(3)
The effects of misoprostol, a prostaglandin E1 analog, and prostaglandin E2 on proteoglycan biosynthesis and loss were studied in unloaded and mechanically loaded mature bovine articular cartilage explants. The prostaglandins were administered daily
Autor:
Ken-ichi Shikada, Sakuya Tanaka
Publikováno v:
Prostaglandins. 51(5)
We have investigated the effect of the K+ channel openers (+)-7,8-dihydro-6, 6-dimethyl-7-hydroxy-8-(2-oxo-piperidin-1-yl)-6H-pyrano[2,3- f]benz-2, 1,3-oxadiazole (NIP-121) and cromakalim on the relaxation induced by the phospholipase A2 activator me
Publikováno v:
Prostaglandins. 46(6)
Intravenously administered endothelin-1 (ET-1) (2×10−11 ∼ 6×10−10 mol/kg) induced dose-dependent pressor responses in anesthetized guinea pigs. Pretreatment with indomethacin (5 mg/kg, i.v.) or with a thromboxane A2/prostaglandin endoperoxide
Publikováno v:
Prostaglandins. 45(1)
Topical application of 250 micrograms of platelet activating factor (PAF) or 5 micrograms of prostaglandin E2 (PGE2) to the rabbit's eye is followed by a rise in intraocular pressure (IOP). The occurrence of PAF in the anterior chamber is held respon
Publikováno v:
Prostaglandins. 44(5)
The release of an endogenous prostacyclin-like factor (PLF) from rat thoracic aorta rings was evaluated through inhibition of platelet ADP-induced aggregation and assessed with a micro-method using 96-multiwell plates. Aggregation was assessed in an