Zobrazeno 1 - 8
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pro vyhledávání: '"Christopher L.-H. Huang"'
Publikováno v:
Progress in Biophysics and Molecular Biology. 98:171-178
Voltage-gated Na+ channels are transmembrane proteins that produce the fast inward Na+ current responsible for the depolarization phase of the cardiac action potential. They play fundamental roles in the initiation, propagation, and maintenance of no
Autor:
Stephen W. Booth, Fergus Simpson, Christopher L.-H. Huang, Sandeep S. Hothi, Yanmin Zhang, Andrew A. Grace, Matthew J. Killeen, Ian N. Sabir
Publikováno v:
Progress in Biophysics and Molecular Biology. 98:267-280
The gain-of-function Scn5a+/DeltaKPQ mutation in the cardiac Na(+) channel causes human long QT type 3 syndrome (LQT3) associated with ventricular arrhythmogenesis. The K(ATP) channel-opener nicorandil (20muM) significantly reduced arrhythmic inciden
Publikováno v:
Progress in Biophysics and Molecular Biology. 98:208-218
Ventricular arrhythmias are the key underlying cause of sudden cardiac death, a common cause of mortality and a significant public health burden. Insights into the electrophysiological basis of such phenomena have been obtained using a wide range of
Publikováno v:
Progress in Biophysics and Molecular Biology. 98:340-346
Recent advances in pharmacological and device-based therapies have provided a range of management options for patients at risk of sudden cardiac death (SCD). Since all such interventions come with their attendant risks, however, stratification proced
Publikováno v:
Progress in Biophysics and Molecular Biology. 94:336-372
The membrane potential (E(m)) is a fundamental cellular parameter that is primarily determined by the transmembrane permeabilities and concentration gradients of various ions. However, ion gradients are themselves profoundly influenced by E(m) due to
Publikováno v:
Progress in biophysics and molecular biology. 98(2-3)
We investigated the effects of reducing sarcoplasmic reticular (SR) Ca(2+) stores using the Ca(2+)-ATPase inhibitor cyclopiazonic acid (CPA) in Langendorff-perfused mouse hearts exposed to different pro-arrhythmic agents all known to produce Ca(2+)-m
Publikováno v:
Progress in biophysics and molecular biology. 98(2-3)
Publikováno v:
Progress in biophysics and molecular biology. 98(2-3)
Sudden cardiac death resulting from ventricular arrhythmogenesis is a leading cause of mortality in the developed world, accounting for up to 400,000 deaths per year in the US alone. Within the past forty years we have taken considerable leaps forwar