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pro vyhledávání: '"Christopher L.-H. Huang"'
Autor:
Stephen W. Booth, Fergus Simpson, Christopher L.-H. Huang, Sandeep S. Hothi, Yanmin Zhang, Andrew A. Grace, Matthew J. Killeen, Ian N. Sabir
Publikováno v:
Progress in Biophysics and Molecular Biology. 98:267-280
The gain-of-function Scn5a+/DeltaKPQ mutation in the cardiac Na(+) channel causes human long QT type 3 syndrome (LQT3) associated with ventricular arrhythmogenesis. The K(ATP) channel-opener nicorandil (20muM) significantly reduced arrhythmic inciden
Publikováno v:
Progress in biophysics and molecular biology. 98(2-3)
Sudden cardiac death resulting from ventricular arrhythmogenesis is a leading cause of mortality in the developed world, accounting for up to 400,000 deaths per year in the US alone. Within the past forty years we have taken considerable leaps forwar