Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Christopher L.-H. Huang"'
Autor:
Stephen W. Booth, Fergus Simpson, Christopher L.-H. Huang, Sandeep S. Hothi, Yanmin Zhang, Andrew A. Grace, Matthew J. Killeen, Ian N. Sabir
Publikováno v:
Progress in Biophysics and Molecular Biology. 98:267-280
The gain-of-function Scn5a+/DeltaKPQ mutation in the cardiac Na(+) channel causes human long QT type 3 syndrome (LQT3) associated with ventricular arrhythmogenesis. The K(ATP) channel-opener nicorandil (20muM) significantly reduced arrhythmic inciden
Publikováno v:
Progress in Biophysics and Molecular Biology. 98:208-218
Ventricular arrhythmias are the key underlying cause of sudden cardiac death, a common cause of mortality and a significant public health burden. Insights into the electrophysiological basis of such phenomena have been obtained using a wide range of
Publikováno v:
Progress in biophysics and molecular biology. 98(2-3)
We investigated the effects of reducing sarcoplasmic reticular (SR) Ca(2+) stores using the Ca(2+)-ATPase inhibitor cyclopiazonic acid (CPA) in Langendorff-perfused mouse hearts exposed to different pro-arrhythmic agents all known to produce Ca(2+)-m
Publikováno v:
Progress in biophysics and molecular biology. 98(2-3)
Sudden cardiac death resulting from ventricular arrhythmogenesis is a leading cause of mortality in the developed world, accounting for up to 400,000 deaths per year in the US alone. Within the past forty years we have taken considerable leaps forwar