Zobrazeno 1 - 10
of 16
pro vyhledávání: '"James P. Allison"'
Autor:
Jennifer A. Wargo, Alexandria P. Cogdill, Alexandre Reuben, James J. Mancuso, Spencer C. Wei, Dana Pe'er, James P. Allison, Jacob H. Levine, Nana Ama A.S. Anang, Roshan Sharma, Miles C. Andrews
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Immune checkpoint blockade therapy has become a critical pillar of cancer therapy. Here, we characterize the cellular mechanisms of monotherapy and combination anti–cytotoxic T lymphocyte antigen-4 plus anti–programmed cell death-1 t
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance To overcome the challenge of nonresponsiveness or low effectiveness to current checkpoint blockade drugs, various combination therapies are under investigation for cancer treatment. In this study, we investigated a combination of Toll-li
Autor:
Amado J. Zurita, John C. Araujo, Harlan Robins, Jingjing Sun, Jianjun Gao, Marissa Vignali, Ana Aparicio, Luis M Vence, Salahaldin A. Tahir, Brinda Rao Korivi, Ryan O. Emerson, Rebecca Slack, Christopher J. Logothetis, Erik Yusko, Sumit K. Subudhi, James P. Allison, Padmanee Sharma
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 113(42)
Immune checkpoint therapies, such as ipilimumab, induce dramatic antitumor responses in a subset of patients with advanced malignancies, but they may also induce inflammatory responses and toxicities termed immune-related adverse events (irAEs). Thes
Autor:
James P. Allison, John C. Morris, Jason C. Steel, Ping Yu, Thomas A. Waldmann, Meili Zhang, Marcella Fasso, Rebecca Waitz
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 109(16)
IL-15 has potential as an immunotherapeutic agent for cancer treatment because of its ability to effectively stimulate CD8 T cell, natural killer T cell, and natural killer cell immunity. However, its effectiveness may be limited by negative immunolo
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 100(18)
B7 family proteins provide costimulatory signals that regulate T cell responses. Here we report the third set of B7 family-related T cell inhibitory molecules with the identification of a homolog of the B7 family, B7x. It is expressed in immune cells
Autor:
Kathleen E. Morton, Linda J. Freezer, Thomas A. Davis, Sharon Mavroukakis, Giao Q. Phan, Nicholas P. Restifo, Paul H. Duray, James P. Allison, Patrick Hwu, James Chih-Hsin Yang, Richard M. Sherry, Douglas J. Schwartzentruber, Seth M. Steinberg, Suzanne L. Topalian, Leah R. Haworth, Claudia A. Seipp, Steven A. Rosenberg
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 100(14)
Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) is a critical immunoregulatory molecule (expressed on activated T cells and a subset of regulatory T cells) capable of down-regulating T cell activation. Blockade of CTLA-4 has been shown in animal
Autor:
Alan J. Korman, James P. Allison, Ann Willman, Michael T. Jaklitsch, Glenn Dranoff, Frank G. Haluska, Michael V. Seiden, Sridhar Shankar, Robert J. Soiffer, Thomas A. Davis, F. Stephen Hodi, Suzanne MacRae, Robert F. Padera, Rochele Henry-Spires, Martin C. Mihm, Marcus O. Butler, Teresa C. Chen
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 100(8)
A large number of cancer-associated gene products evoke immune recognition, but host reactions rarely impede disease progression. The weak immunogenicity of nascent tumors contributes to this failure in host defense. Therapeutic vaccines that enhance
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 97(23)
We examined how cytotoxic T lymphocyte antigen-4 (CTLA-4) regulates heterogeneous CD4+T cell responses by using experimental autoimmune encephalomyelitis (EAE), a CD4+T cell-mediated disease that is subject to regulation by CTLA-4. Disease incidence
Autor:
Christopher Madias, Maurice B. Burg, James P. Allison, Arthur A. Hurwitz, Eugene D. Kwon, Norman M. Greenberg, Barbara A. Foster
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 96(26)
Cancer relapse after surgery is a common occurrence, most frequently resulting from the outgrowth of minimal residual disease in the form of metastases. We examined the effectiveness of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) blockade as
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 95(17)
Generation of a T cell-mediated antitumor response depends on T cell receptor engagement by major histocompatibility complex/antigen as well as CD28 ligation by B7. CTLA-4 is a second B7 receptor expressed by T cells upon activation that, unlike CD28