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pro vyhledávání: '"Alberto Estevez"'
Autor:
Peter Liu, Alberto Estevez, Erin C. Dueber, Vishva M. Dixit, Claudio Ciferri, Monica Gonzalez Ramirez, Aaron Gupta, Robin A. Aglietti, Nobuhiko Kayagaki
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 113(28)
Gasdermin-D (GsdmD) is a critical mediator of innate immune defense because its cleavage by the inflammatory caspases 1, 4, 5, and 11 yields an N-terminal p30 fragment that induces pyroptosis, a death program important for the elimination of intracel
Autor:
Alexandra Minn, Azadeh Madjidi, Vicki Chiang, Jesus Rondon, Bernard B. Allan, Christopher M. Koth, Susmith Mukund, Isidro Hötzel, Yingnan Zhang, Holly J. Clarke, Jeremy Murray, Elizabeth Luis, Alberto Estevez, Wong Terence
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 109(36)
Members of the class B family of G protein-coupled receptors (GPCRs) bind peptide hormones and have causal roles in many diseases, ranging from diabetes and osteoporosis to anxiety. Although peptide, small-molecule, and antibody inhibitors of these G