Zobrazeno 1 - 10
of 69
pro vyhledávání: ''
Autor:
Larry Rodriguez, Yao Lu, Daryl L. Davies, Beza A Dagne, Eric R. Gross, Noëlie S Cayla, M. Bruce MacIver, Boris D. Heifets, Edward J. Bertaccini, M. Frances Davies, Yun Wu
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 116(31)
Intravenous anesthetic agents are associated with cardiovascular instability and poorly tolerated in patients with cardiovascular disease, trauma, or acute systemic illness. We hypothesized that a new class of intravenous (IV) anesthetic molecules th
Autor:
Dennis S. Charney, Scott J. Russo
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 110(12)
Over the past 50 y, there have been few mechanistically distinct drugs for the treatment of major depressive disorders, despite the fact that nearly two-thirds of patients do not achieve full remission of symptoms on currently available antidepressan
Autor:
Lan Bao, Han-Cheng Zheng, Zhen-Ning Zhang, Kai-Cheng Li, Shengxi Wu, Haibo Wang, Qiong Wang, Shao Qiu He, Yan-Qing Zhong, Xu Zhang, Yin-Jing Lu, Zi-Yan Li, Bo Zhao, Tomas Hökfelt
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 107(29)
Morphine-induced analgesia and antinociceptive tolerance are known to be modulated by interaction between δ-opioid receptors (DORs) and μ-opioid receptors (MORs) in the pain pathway. However, evidence for expression of DORs in nociceptive small-dia
Autor:
Bruce D. Hammock, Ming Xu, Yi Zhu, John Y.-J. Shyy, Ding Ai, Nan Li, Youyi Zhang, Jun Yang, Paul D. Jones, Wei Pang, Nipavan Chiamvimonvat
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 106(2)
Pathophysiological cardiac hypertrophy is one of the most common causes of heart failure. Epoxyeicosatrienoic acids, hydrolyzed and degraded by soluble epoxide hydrolase (sEH), can function as endothelium-derived hyperpolarizing factors to induce dil
Autor:
Mei-Fang Chen, Hung Wen Lin, Po-Yi Chen, Chao-Zong Liu, Louis S. Premkumar, Alex F. Chen, Deshou Cao, Donald S. Torry, Mansoor Mozayan, Shinn-Zong Lin, Tony J.-F. Lee
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 105(49)
Nitric oxide (NO) is identified as the endothelium-derived relaxing factor and a neurotransmitter with a superfusion bioassay cascade technique. By using a similar technique with rat superior cervical ganglion (SCG) as donor tissue and rabbit endothe
Autor:
Ding Ai, Nanping Wang, Yi Zhu, Chaoshu Tang, Bruce D. Hammock, Hiromasa Tanaka, Yi Fu, Deliang Guo, John Y.-J. Shyy
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 104(21)
Epoxyeicosatrienoic acids (EETs), as metabolites of arachidonic acid, may function as antihypertensive and antiatherosclerotic mediators for vasculature. EETs are degraded by soluble epoxide hydrolase (sEH). Pharmacological inhibition and genetic abl
Autor:
Ginger Y. Wu, Mark E. Salvati, Yongmi An, Ricardo M. Attar, John S. Sack, Kevin Kish, Chihuei Wang, Susan E. Kiefer, Roberto Weinmann, Stanley R. Krystek, Howard Einspahr, Julie E Scheffler
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 98(9)
The structures of the ligand-binding domains (LBD) of the wild-type androgen receptor (AR) and the T877A mutant corresponding to that in LNCaP cells, both bound to dihydrotestosterone, have been refined at 2.0 Å resolution. In contrast to the homod
Autor:
Suhayla Mukaddam-Daher, Marek Jankowski, Fadi Hajjar, Donghao Wang, Jolanta Gutkowska, Samuel M. McCann
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 97(11)
Produced and released by the heart, oxytocin (OT) acts on its cardiac receptors to decrease the cardiac rate and force of contraction. We hypothesized that it might also be produced in the vasculature and regulate vascular tone. Consequently, we prep
Autor:
Esther García-Palomero, Carlos J. Herrero, Luis Gandía, Inés Mayorgas, Antonio G. García, Manuela G. López, J M McIntosh, Baldomero M. Olivera, Román Olivares, Mercedes Villarroya, J. M. Hernández-Guijo, Carmen Montiel
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 95(24)
Methyllycaconitine (MLA), α-conotoxin ImI, and α-bungarotoxin inhibited the release of catecholamines triggered by brief pulses of acetylcholine (ACh) (100 μM, 5 s) applied to fast-superfused bovine adrenal chromaffin cells, with IC 50 s of 100 nM
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 95(23)
Previously, we showed that retinoic acid (RA) binds to the mannose-6-phosphate/insulin-like growth factor II receptor (M6P/IGF2R) with high affinity, suggesting that M6P/IGF2R may be a receptor for RA. Here, we show that RA, after 2–3 h of incubati