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pro vyhledávání: ''
Autor:
Bruce D. Hammock, Ming Xu, Yi Zhu, John Y.-J. Shyy, Ding Ai, Nan Li, Youyi Zhang, Jun Yang, Paul D. Jones, Wei Pang, Nipavan Chiamvimonvat
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 106(2)
Pathophysiological cardiac hypertrophy is one of the most common causes of heart failure. Epoxyeicosatrienoic acids, hydrolyzed and degraded by soluble epoxide hydrolase (sEH), can function as endothelium-derived hyperpolarizing factors to induce dil
Autor:
Patrizia Porcu, P. Grisenti, Maria Cristina Mostallino, Maria Luisa Barbaccia, Marco Trabucchi, Alessandra Concas, Paolo Follesa, Robert H. Purdy, Giovanni Biggio
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 95(22)
The relation between changes in brain and plasma concentrations of neurosteroids and the function and structure of γ-aminobutyric acid type A (GABA A ) receptors in the brain during pregnancy and after delivery was investigated in rats. In contrast
Autor:
Di Lu, Sanford P. Bishop, Phyllis Y. Reaves, Jeffrey R. Martens, Kathleen H. Berecek, Michael J. Katovich, Craig H. Gelband, Mohan K. Raizada
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 95(5)
Hypertension produces pathophysiological changes that are often responsible for the mortality associated with the disease. However, it is unclear whether normalizing blood pressure (BP) with conventional therapy is effective in reversing the pathophy
Autor:
G. M. Anderson, M.-P. Wautier, Shi Du Yan, L Capron, O. Chappey, Osamu Hori, Clotilde Zoukourian, J Brett, Jean-Luc Wautier, Ann Marie Schmidt
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 91(16)
Vascular complications are an important cause of morbidity and mortality in patients with diabetes. The extent of vascular complications has been linked statistically to enhanced adherence of diabetic erythrocytes to endothelial cells (ECs) and to th
Autor:
Mark L. Failla, Shukal Bala
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 89(15)
The essentiality of adequate copper (Cu) nutriture for normal T-cell function in laboratory and domestic animals is well established. However, specific biochemical roles of Cu in the maturation and activation of T cells have not been defined. Previou
Autor:
F A McMorris
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 74(10)
Addition of 1 micronM 1-norepinephrine to cultures of C6TK- rat glioma cells caused a 2-fold increase in specific activity of the glial-specific enzyme 2':3'-cyclic nucleotide 3'-phosphohydrolase (nucleoside-2':3'-cyclic-phosphate 3'-nucleotidohydrol
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 84(9)
1,25-Dihydroxyvitamin D3, the hormonal form of vitamin D3, promotes the differentiation of HL-60 human promyelocytic leukemia cells into monocytes. Differentiation changes include the induction of phagocytosis, the initiation of nitroblue tetrazolium
Autor:
Robert N. McBurney, John F. W. Keana, Michael W. Scherz, C Jahr, Steven Finkbeiner, J B Fischer, P N Hamilton, S M Smith, Courtney Stevens, A C Server
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 86(14)
Four diarylguanidine derivatives were synthesized. These compounds were found to displace, at submicromolar concentrations, 3H-labeled 1-[1-(2-thienyl)cyclohexyl]piperidine and (+)-[3H]MK-801 from phencyclidine receptors in brain membrane preparation
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 86(22)
Rats infused with a supramaximally stimulating dose of the cholecystokinin (CCK) analog caerulein develop acute edematous pancreatitis. Using CCK-JMV-180, a recently developed CCK analog that acts as an agonist at high-affinity CCK receptors but anta