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Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 89(16)
We have previously reported the selective amplification of several rat striatal cDNA sequences that encode guanine nucleotide-binding regulatory protein (G protein)-coupled receptors. One of these sequences (R226) exhibited high sequence identity (58
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 83(16)
A cDNA clone for the rat glucocorticoid receptor (GR) was used to study mechanisms of GR mRNA regulation. Treatment of rat hepatoma culture cells with 0.5 microM dexamethasone caused a small, initial increase in the GR mRNA level after 6 hr as well a
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 79(14)
The glucocorticoid-receptor complex can be subdivided into three separate domains by limited proteolysis with trypsin or alpha-chymotrypsin. The following characteristics can be separated: steroid-binding activity (domain A), DNA-binding activity (do
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 84(5)
DBI (diazepam-binding inhibitor) is a putative neuromodulatory peptide isolated from rat brain that acts on gamma-aminobutyric acid-benzodiazepine-Cl- ionophore receptor complex inducing beta-carboline-like effects. We used a cDNA probe complementary
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 68(7)
Cytoplasmic fractions containing steroid hormone receptor were prepared from rat prostate and uterine tissues, incubated first with [ 3 H]dihydrotestosterone or [ 3 H]estradiol, and then with their respective target and non-target tissue chromatins.