Zobrazeno 1 - 10
of 2 077
pro vyhledávání: ''
Autor:
Matthew E. Cockman, Yoichiro Sugimoto, Hamish B. Pegg, Norma Masson, Eidarus Salah, Anthony Tumber, Helen R. Flynn, Joanna M. Kirkpatrick, Christopher J. Schofield, Peter J. Ratcliffe
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(32)
The Jumonji domain–containing protein JMJD6 is a 2-oxoglutarate–dependent dioxygenase associated with a broad range of biological functions. Cellular studies have implicated the enzyme in chromatin biology, transcription, DNA repair, mRNA splicin
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(20)
The placenta is a transient but important multifunctional organ crucial for healthy pregnancy for both mother and fetus. Nevertheless, limited access to human placenta samples and the paucity of a proper in vitro model system has hampered our underst
Autor:
Jeremy N. Rich, Zengqiang Yuan, Rong Wu, Qi Xie, Xiao-Song Chen, Yuhao Gao, Qing He, Liang Wang, Kun-Wei Shen, Ryan C. Gimple, Yajin Liao
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Adipocytes are the most abundant and perhaps most active components of the tumor microenvironment in obese individuals that potentiate breast tumorigenesis through secretory mechanisms. The modulation of adipocytes can be novel therapy t
Autor:
Rachel Leicher, Tom W. Muir, Bin Zhang, Matthew J. Reynolds, Xingcheng Lin, Eva J. Ge, Wen Jun Xie, Thomas Walz, Shixin Liu
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Polycomb repressive complex 2 (PRC2) is a major epigenetic machinery that maintains transcriptionally silent heterochromatin in the nucleus and plays critical roles in embryonic development and oncogenesis. It is generally thought that P
Autor:
Maria Victoria Revuelta, Leandro Cerchietti, Jadwiga Gasiorek, Victoria H. Cowling, Lucy Skrabanek, Biljana Culjkovic-Kraljacic, Katherine L. B. Borden
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Methyl-7-guanosine (m7G) “cap” addition on 5′ ends of RNA impacts virtually all levels of processing. Titrating capping of transcripts impacts on protein-coding capacity and, for noncoding RNAs, biochemical activity. Capping is wid
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Recently, the field of Parkinson’s disease biology has shifted attention away from pure proteinotoxic hypotheses to emphasize primary cellular insults, including glycolipid disturbances. In this work, dopaminergic neurons in the Parkin
Autor:
Stephen J. Pratt, Eleanor C Ory, Erick O. Hernández-Ochoa, Joseph P. Stains, Martin F. Schneider, Patrick C. Bailey, Julia A. Ju, Keyata Thompson, Christopher W. Ward, Trevor J. Mathias, Katarina T. Chang, David A Annis, Michele Vitolo, Rachel M. Lee, Stuart S. Martin
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance In breast cancer, the chronically stiffening mechanical microenvironment promotes tumor growth/invasion. However, the molecular details and integration of cancer mechanotransduction signaling pathways are not well understood. We find tha
Autor:
Shima Rayatpisheh, James A. Wohlschlegel, Robert H. Brown, Hirosha Geekiyanage, Victor R. Ambros
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance MicroRNAs (miRNAs) are abundant inside cells, where they regulate gene expression posttranscriptionally, but are also found in circulation as remarkably stable extracellular constituents of body fluids such as human blood plasma and cere
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Alzheimer’s disease (AD) has complex pathological mechanisms. Our limited understanding of the molecular and cellular changes in AD hindered the identification of therapeutic targets. In this study, we profiled 169,496 nuclei from the
Autor:
Hongbo Hu, Shiqian Qi, Huiyuan Zhang, Tingting Yang, Zhonghan Li, Qing-Yuan Sun, Yike Yin, Huancheng Fu, Dan Tang, Wenming Xu, Xueying Fan, Jingfei Xiong, Biao Dong, Qiuyue Huang, Lunzhi Dai, Yuliang Liu, Kun Xie, Shiyu Cao, Fuping Li, Tie-Gang Meng, Ling Nie, Yu Liu
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance NOD-like receptors (NLRs) are traditionally recognized as key surveillance pattern recognition receptors (PRRs) during innate immune regulation. Several NLRs exhibit highly restricted expression in mammalian germline, where their physiol