Zobrazeno 51 - 60
of 2 077
pro vyhledávání: ''
Autor:
Sung Hoon Kim, Kathryn E. Carlson, Tina Izard, Benita S. Katzenellenbogen, Scott J. Novick, Jerome C. Nwachukwu, René Houtman, Charles C. Nettles, Yingwei Hou, Sathish Srinivasan, Jian Min, Yvonne S. Ziegler, Kendall W. Nettles, Shunchao Yan, Patrick R. Griffin, Bruce D. Pascal, John A. Katzenellenbogen, Charles K Min, Valeria Sanabria Guillen, Erumbi S. Rangarajan, Jacqline W Njeri
Publikováno v:
Proc Natl Acad Sci U S A
Efforts to improve estrogen receptor-α (ER)-targeted therapies in breast cancer have relied upon a single mechanism, with ligands having a single side chain on the ligand core that extends outward to determine antagonism of breast cancer growth. Her
Autor:
Yan-Hong Cui, Gayoung Park, Chuan He, Seungwon Yang, Yu-Ying He, Jiangbo Wei, Zizhao Yang, Palak Shah, Xiaolong Cui
Publikováno v:
Proc Natl Acad Sci U S A
Global genome repair (GGR), a subpathway of nucleotide excision repair, corrects bulky helix-distorting DNA lesions across the whole genome and is essential for preventing mutagenesis and skin cancer. Here, we show that METTL14 (methyltransferase-lik
Publikováno v:
Proc Natl Acad Sci U S A
Manganese (Mn) is an essential metal that induces incurable parkinsonism at elevated levels. However, unlike other essential metals, mechanisms that regulate mammalian Mn homeostasis are poorly understood, which has limited therapeutic development. H
Autor:
Sanjeev Das, Madhurima Ghosh
Publikováno v:
Proc Natl Acad Sci U S A
PRAMEF2 is a member of the PRAME multigene family of cancer testis antigens, which serve as prognostic markers for several cancers. However, molecular mechanisms underlying its role in tumorigenesis remain poorly understood. Here, we report that PRAM
Autor:
Howard A. Young, Enitome E. Bafor
Publikováno v:
Proc Natl Acad Sci U S A
In the 19th century, Ilya Metchnikoff defined and broadened our initial understanding of phagocytosis and, in 1908, went on to show that a cellular component (i.e., DNA) stimulates immune responses (1). About a century later, Janeway conceptualized p
Autor:
Jan-Sebastian Grigoleit, Alex Reed, Haoxin Li, Sabrina Barbas, Olesya A. Ulanovskaya, Benjamin F. Cravatt, Hui Jing, Kim Masuda, Jason Germain, Cassandra L. Henry, Dylan M. Herbst
Publikováno v:
Proc Natl Acad Sci U S A
Human genetic studies have pointed to a prominent role for innate immunity and lipid pathways in immunological and neurodegenerative disorders. Our understanding of the composition and function of immunomodulatory lipid networks in innate immune cell
Autor:
Adam C. Straub, Damir Kračun, Eugenia Cifuentes-Pagano, Evan DeVallance, Patrick J. Pagano, Mohamed El Massry, Christopher M Dustin, Aditi U. Gurkar, Toren Finkel, Cynthia St. Hilaire, Yao Li, Shuai Yuan, Christian J Goossen, Sanghamitra Sahoo
Publikováno v:
Proc Natl Acad Sci U S A
In an aging population, intense interest has shifted toward prolonging health span. Mounting evidence suggests that cellular reactive species are propagators of cell damage, inflammation, and cellular senescence. Thus, such species have emerged as pu
Autor:
Victor D. Vacquier
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
In the second half of the 1800s biologists began to investigate the cellular basis of development. Sea urchins became a favorite material for this endeavor because their gametes can be obtained in vast numbers and fertilization and development are ex
Publikováno v:
Proc Natl Acad Sci U S A
Significance Neutrophils provide first-line host defense by migrating through chemoattractant gradients to the sites of inflammation. The inappropriate recruitment and misregulated activation of neutrophils contribute to tissue damage and cause autoi
Autor:
Ross L. Levine, Daniel A Michelson, Kushagra Bansal, Christophe Benoist, Diane Mathis, Aaron D. Viny, Ricardo Ramirez
Publikováno v:
Proc Natl Acad Sci U S A
Aire controls immunological tolerance by driving promiscuous expression of a large swath of the genome in medullary thymic epithelial cells (mTECs). Its molecular mechanism remains enigmatic. High-resolution chromosome-conformation capture (Hi-C) exp