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Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Our study establishes TiPARP as a turning-off mechanism for a number of important transcription factors, including HIF-1, c-Myc, and estrogen receptor. The study also establishes that TiPARP forms nuclear condensates in an ADP ribosylati
Autor:
Rui Zhao, Jing Zhang, Lei Shi, Ning Zhu, Aihong Mao, Yuxin Wang, Jing Nan, Yuping Du, Xing Chen, Zhao Zhang, Xinxin Zhang, Yuxi Lin, Jinbo Yang, George R. Stark, Wei Wei, Jingjie Sun, Ruidong Miao, Xin Li, Xiaodong Qin
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Tamoxifen is beneficial in treating estrogen receptor–positive breast cancer, but resistance to this treatment eventually ensues. A method to identify mechanisms of tamoxifen resistance identified the histone deacetylase ZIP, leading t
Autor:
Roland Wedlich-Söldner, Tim Krischuns, Hannes C.A. Drexler, Laurita Boff, Stephan Ludwig, Christian Schuberth, Darisuren Anhlan, André Schreiber, Linda Brunotte
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Influenza viruses (IV) replicate in the nucleus. Export of newly produced genomes, packaged in viral ribonucleoprotein (vRNP) complexes, relies on the nuclear CRM1 export pathway and appears to be timely controlled by virus-induced cellu
Autor:
Xiangyang Wang, Mingkang Jia, Chuanmao Zhang, Qing Jiang, Qiaoyu Lin, Shicong Zhu, Fan Huang, Gan Zhao, Bin Yu, Nan Xu, He Ren
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Barrier-to-autointegration factor (BAF), a highly conserved small protein in metazoans, plays multiple functions during the cell cycle; however, the regulation of BAF function is largely unclear. Here we find that the SUMOylation and de-
Autor:
Raffaella Iurlaro, Jaime Redondo-Pedraza, Sandrine Marchetti, Eric Eldering, Ernest Nadal, Jean-Ehrland Ricci, Cristina Muñoz-Pinedo, Franziska Püschel, Blanca Majem, Francesca Favaro, Eric Chevet, Estefanía Lucendo
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2020, 117 (18), pp.9932-9941. ⟨10.1073/pnas.1913707117⟩
Proceedings of the National Academy of Sciences of the United States of America, 117(18), 9932-9941. National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America, 2020, 117 (18), pp.9932-9941. ⟨10.1073/pnas.1913707117⟩
Proceedings of the National Academy of Sciences
Dipòsit Digital de la UB
Universidad de Barcelona
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2020, 117 (18), pp.9932-9941. ⟨10.1073/pnas.1913707117⟩
Proceedings of the National Academy of Sciences of the United States of America, 117(18), 9932-9941. National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America, 2020, 117 (18), pp.9932-9941. ⟨10.1073/pnas.1913707117⟩
Proceedings of the National Academy of Sciences
Dipòsit Digital de la UB
Universidad de Barcelona
Significance Poorly irrigated tumors exhaust nutrients from their environment. On the other hand, innate immune cells, such as neutrophils and macrophages, have been frequently shown to infiltrate tumors and promote an immunosuppressive environment.
Autor:
Taichi Noda, Martin M. Matzuk, Asami Oji, Masahito Ikawa, Kanako Kojima-Kita, Zhifeng Yu, Yoshitaka Fujihara, Ryan M. Matzuk, Tamara Larasati, Yonggang Lu
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Fujihara, Y., Lu, Y., Noda, T., Oji, A., Larasati, T., Kojima-Kita, K., . . . Ikawa, M. (2020). Spermatozoa lacking fertilization influencing membrane protein (FIMP) fail to fuse with oocytes in mice. Proceedings of the National Academy of Sciences o
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance How do variants that cause autosomal dominant polycystic kidney disease (ADPKD) alter the structure and function of polycystin-2 channels? This 20-y-old question remains unanswered because polycystins traffic to organelle membranes, such
Autor:
Mark Stettner, Linda Groeneweg, Anne K. Mausberg, Michael Heming, Clara Frydrychowicz, Ruth M. Stassart, Robert Fledrich, Xiaolin Li, Jolien Wolbert, Heinz Wiendl, Dagmar Akkermann, Gerd Meyer zu Hörste, Christian Schulz, Noelia Alonso Gonzalez
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance We here present a transcriptional map of peripheral nerve cells in health and autoimmunity. Identified marker genes of nonmyelinating Schwann cells and nerve-associated fibroblasts will facilitate a better understanding of the complex ce
Autor:
Jennifer Vandooren, Jack van Horssen, Ivo Lambrichts, Melissa Schepers, Chris Van den Haute, Ghislain Opdenakker, Helena Slaets, Wia Baron, Veerle Baekelandt, Niels Hellings, Tim Vanmierlo, Evelien Houben, Doryssa Hermans, Bieke Broux, Kris Janssens
Publikováno v:
Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences of the United States of America, 117(9), 5028-5038. National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America, 117(9), 5028-5038. NATL ACAD SCIENCES
Houben, E, Janssens, K, Hermans, D, Vandooren, J, van den Haute, C, Schepers, M, Vanmierlo, T, Lambrichts, I, van Horssen, J, Baekelandt, V, Opdenakker, G, Baron, W, Broux, B, Slaets, H & Hellings, N 2020, ' Oncostatin M-induced astrocytic tissue inhibitor of metalloproteinases-1 drives remyelination ', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 9, pp. 5028-5038 . https://doi.org/10.1073/pnas.1912910117
Article
Proceedings of the National Academy of Sciences of the United States of America, 117(9), 5028-5038. National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America, 117(9), 5028-5038. NATL ACAD SCIENCES
Houben, E, Janssens, K, Hermans, D, Vandooren, J, van den Haute, C, Schepers, M, Vanmierlo, T, Lambrichts, I, van Horssen, J, Baekelandt, V, Opdenakker, G, Baron, W, Broux, B, Slaets, H & Hellings, N 2020, ' Oncostatin M-induced astrocytic tissue inhibitor of metalloproteinases-1 drives remyelination ', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 9, pp. 5028-5038 . https://doi.org/10.1073/pnas.1912910117
Article
The brain's endogenous capacity to restore damaged myelin deteriorates during the course of demyelinating disorders. Currently, no treatment options are available to establish remyelination. Chronic demyelination leads to damaged axons and irreversib
Autor:
Mingqun Lin, Sriram Subramaniam, Yasuko Rikihisa, Lisa M. Hartnell, Giovanna Grandinetti, Donald Bliss
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Biological membranes are essential for life. Although bacteria and eukaryotic cells have evolved to produce membranes of different compositions, several bacterial pathogens can hijack and utilize host-synthesized membrane lipids. Here, w