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Autor:
Eamonn Sheridan, Ellanor L. Whiteley, Tarek Z. Deeb, Roland Bürli, Nicholas J. Brandon, Gonzalo S. Tejeda, George S. Baillie, Stephen J. Moss
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Phosphodiesterase 10A (PDE10A) is as a target of interest in Huntington’s disease (HD) as levels of the enzyme have been shown to decrease prior to the development of the hallmark motor symptoms. Clearly, a better understanding of how
Autor:
Yu, Jia, Shi, Yue, Zhao, Kaixuan, Yang, Guang, Yu, Lina, Li, Yuxin, Andersson, Eva-Marie, Ämmälä, Carina, Yang, Shao-Nian, Berggren, Per-Olof
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance We reveal that increased expression of CaV3.1 channels in rat islets selectively impairs first-phase glucose-stimulated insulin secretion. This deterioration is recapitulated in human islets. Its causal role in diabetes development is cl
Autor:
J. Alexandra Rowe, Jianbing Mu, Louis H. Miller, Yvonne Azasi, Ashfaq Ghumra, Gabriella Lindergard
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Azasi, Y, Lindergard, G, Ghumra, A, Mu, J, Miller, L H & Rowe, J A 2018, ' Infected erythrocytes expressing DC13 PfEMP1 differ from recombinant proteins in EPCR-binding function ', Proceedings of the National Academy of Sciences, vol. 115, no. 5, pp. 1063-1068 . https://doi.org/10.1073/pnas.1712879115
Azasi, Y, Lindergard, G, Ghumra, A, Mu, J, Miller, L H & Rowe, J A 2018, ' Infected erythrocytes expressing DC13 PfEMP1 differ from recombinant proteins in EPCR-binding function ', Proceedings of the National Academy of Sciences, vol. 115, no. 5, pp. 1063-1068 . https://doi.org/10.1073/pnas.1712879115
Significance Sequestration of Plasmodium falciparum-infected erythrocytes (IEs) in the brain microvasculature underlies the pathology of cerebral malaria. Parasites that express P. falciparum erythrocyte membrane protein 1 of domain cassette (DC) 8 a
Autor:
Marta Campiglio, Nadine J. Ortner, Petronel Tuluc, Bernhard E. Flucher, Van Petegem F, Costé de Bagneaux P
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Association of the adaptor protein STAC3 to the calcium channel was recently identified as essential for skeletal muscle contraction. While STAC3 is expressed exclusively in skeletal muscle, the other two isoforms, STAC1 and STAC2, are f
Autor:
Peter W. Lewis, Stefan M. Lundgren, Tom W. Muir, Eva J. Ge, Krupa S. Jani, Manuel M. Müller, Siddhant U. Jain, Katharine L. Diehl
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 116(17)
Enhancer of Zeste Homolog 2 (EZH2) is the catalytic subunit of Polycomb Repressor Complex 2 (PRC2), the enzyme that catalyzes monomethylation, dimethylation, and trimethylation of lysine 27 on histone H3 (H3K27). Trimethylation at H3K27 (H3K27me3) is
Autor:
Xiaoxia Li, Kevin Sun, Caini Liu, Xing Chen, Gang Cai, Liang Zhu, Jun Qin, Ganes C. Sen, George Stark Stark
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 115(45)
The activation of the epidermal growth factor receptor (EGFR) is crucial for triggering diverse cellular functions, including cell proliferation, migration, and differentiation, and up-regulation of EGFR expression or activity is a key factor in trig
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 115(41)
ZFAND5/ZNF216, a member of the zinc finger AN1-type domain family, is abundant in heart and brain, but is induced in skeletal muscle during atrophy (although not in proteotoxic stress). Because mice lacking ZFAND5 exhibit decreased atrophy, a role in
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 115(26)
In aerobically growing cells, the guanine base of RNA is oxidized to 8-oxo-7,8-dihydroguanine (8-oxoG), which induces alteration in their gene expression. We previously demonstrated that the human AUF1 protein binds to 8-oxoG in RNA to induce the sel
Autor:
Jenna M. Antonucci, Zhihua Qin, Li Wu, Olga Buzovetsky, Yong Xiong, Denis C. Guttridge, Mario L. Santiago, Katherine J. Ladner, Bradley S. Barrett, Jacob S. Yount, Corine St. Gelais, Karthik M. Kodigepalli, Kirsten M. Knecht, Serena Bonifati, Shuliang Chen, Sun Hee Kim
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 115(16)
Sterile alpha motif and HD-domain-containing protein 1 (SAMHD1) blocks replication of retroviruses and certain DNA viruses by reducing the intracellular dNTP pool. SAMHD1 has been suggested to down-regulate IFN and inflammatory responses to viral inf
Autor:
Shakiba P. Baniasadi, Zhenyue Hao, Yi Sheng, Jillian Haight, Lisa Jones, Kelsie L. Thu, Carmen Dominguez-Brauer, Rahima Khatun, Andrew J. Elia, Tak W. Mak, Parameswaran Ramachandran
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 114(7)
Wnt signaling, named after the secreted proteins that bind to cell surface receptors to activate the pathway, plays critical roles both in embryonic development and the maintenance of homeostasis in many adult tissues. Two particularly important cell