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Autor:
Michelle Shen, Christian A. Kunder, Aimen Zlitni, Meghan A. Rice, Chiyuan Amy Zhang, Merve Aslan, Sahil Kumar, Fernando Jose Garcia Marques, Kashyap Koul, Shiqin Liu, Abel Bermudez, Frezghi Habte, Donna M. Peehl, Tanya Stoyanova, Amina Zoubeidi, En-Chi Hsu, James D. Brooks, Sanjiv S. Gambhir, Ali Ghoochani, Yun Sheng Chen, Sharon J. Pitteri, Rosalie Nolley
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance NEPC is a highly aggressive subtype of prostate cancer that is increasing in incidence, likely due to use of new secondary androgen deprivation therapies. Here, we demonstrate that Trop2 is significantly elevated in CRPC and NEPC and rep
Autor:
Clare M. Adams, William P. Tansey, Joy Creighton, April M. Weissmiller, Qi Liu, Stephen W. Fesik, Lance R. Thomas, Christine M. Eischen, Shelly L. Lorey, Jing Wang
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance The oncoprotein transcription factor MYC is a validated but challenging anticancer target. In this work, we show that WDR5—a well-structured protein with druggable pockets—could be a focal point for effective anti-MYC therapies. We d
Autor:
Patricia L. Opresko, Simon C. Watkins, Namrata Kumar, Dmytro Kolodieznyi, Vera Roginskaya, Marcel P. Bruchez, Elise Fouquerel, Bennett Van Houten, Wei Qian, Sruti Shiva
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance It is highly controversial whether secondary reactive oxygen species generated by dysfunctional mitochondria are able to diffuse across the cytoplasm to the nucleus and cause subsequent nuclear changes. We have developed a targeted chemo
Autor:
Graham J. Burton, Hong Wa Yung, Emilie Dommett, Tereza Cindrova-Davies, Andrew J. Murray, F. Colleoni, John Kingdom
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Preeclampsia endangers the lives and well-being of mother and baby. The syndrome is associated with placental dysfunction. High demand for energy to support active nutrient transport and hormone production increases placental susceptibil
Autor:
Hongyu Guan, Zhu Ting, Mengfeng Li, Liu Bangdong, Shanshan Wu, Jun Li, Junchao Cai, Xin Zhang, Erwei Song, Jueheng Wu, Shihua Liu, Mu Sheng Zeng, Xun Zhu
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance This study uncovers a long noncoding RNA (lncRNA)-mediated mechanism underlying lung adenocarcinoma (LAD) metastasis. We here report that lncRNA LINC00673-v4 expression is up-regulated in LAD and is associated with disease progression. A
Autor:
Greg G. Jones, Sibel Sari, Pablo Rodriguez-Viciana, Nicole Hartig, Amandeep Bhamra, Ewa Rejnowicz, Isabel Boned del Río, Benjamin Ringham-Terry, Winnie Lei, Lucy C. Young, Silvia Surinova
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, vol 116, iss 27
Proceedings of the National Academy of Sciences of the United States of America, vol 116, iss 27
Significance The ERK signaling pathway is hyperactivated in a majority of cancers. However, because it mediates myriad physiological responses, the clinical efficacy of current ERK pathway inhibitors has been severely limited by toxicity. This study
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance An obligatory step in the replication cycle of all retroviruses involves reverse transcription of their RNA genomes into double-stranded DNA for integration into the host cell chromosome. The process of synthesizing double-stranded HIV-1
Autor:
Bohumil Fafilek, Peter Konik, Iva Gudernova, Jennifer Zieba, Miroslav Varecha, Sara P. Abraham, Tomas Gregor, Ivan Duran, David Šmajs, Gert Jansen, Marketa Tomanova, Pavel Krejci, So Hyun Park, Jieun Song, Tomáš Bárta, Deborah Krakow, Lukas Balek, Alexandru Nita, David Potesil, Zheng Fu, Neha Basheer, Hyuk Wan Ko, Aleš Hampl, Michaela Bosakova, Jana Kučerová, Juraj Bosák, Lukáš Trantírek, Zbynek Zdrahal
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the U.S.A., 116(10), 4316-4325. National Academy of Sciences
Proceedings of the National Academy of Sciences of the U.S.A., 116(10), 4316-4325. National Academy of Sciences
Significance A properly functioning primary cilium is prerequisite for both normal development and aging of all ciliated organisms, including humans. In vertebrates, the signaling of Hedgehog family morphogens depends entirely on primary cilium. Rece
Autor:
Deborah K. Morrison, Daniel A. Ritt, Christopher J. Westlake, Elizabeth M. Terrell, Pradeep Kota, Christine Insinna
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Noonan syndrome belongs to a group of related developmental disorders termed the RASopathies, and both the M-Ras GTPase and its effector Shoc2 are signaling proteins mutated in specific subtypes of this disorder. Previously, the M-Ras/Sh
Autor:
Daniel Blanco-Melo, Maryline Panis, Julie Eggenberger, Benjamin R. tenOever, Kristen J. Brennand
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Unlike all differentiated cells, pluripotent stem cells do not elicit a productive antiviral response when infected by a pathogen. This observation seems at odds with the importance of pluripotent stem cells given their absolute requirem